AngioJet Thrombectomy Versus Catheter-Directed Thrombolysis for Lower Extremity Deep Vein Thrombosis: A Meta-Analysis of Clinical Trials
| Autor: | Xi Cheng Zhang, Lei Wang, Guan Qiang Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_treatment Deep vein Catheter directed thrombolysis 030204 cardiovascular system & hematology deep vein thrombosis 03 medical and health sciences Therapeutic Approaches for the Treatment of Cerebral-Neurovascular Diseases 0302 clinical medicine Risk Factors Medicine Humans Thrombolytic Therapy 030212 general & internal medicine Thrombectomy catheter-directed thrombolysis Venous Thrombosis business.industry Incidence (epidemiology) Significant difference Hematology General Medicine Thrombolysis AngioJet medicine.disease Thrombosis Clinical trial medicine.anatomical_structure Treatment Outcome Lower Extremity lcsh:RC666-701 Meta-analysis Anesthesia Female Original Article business |
| Zdroj: | Clinical and Applied Thrombosis/Hemostasis Clinical and Applied Thrombosis/Hemostasis, Vol 27 (2021) |
| ISSN: | 1938-2723 |
| Popis: | Early catheter-directed thrombolysis (CDT) for lower extremity deep vein thrombosis (LEDVT) can reduce post-thrombotic morbidity and the AngioJet thrombectomy is a new therapy that can be selected for the treatment of LEDVT. We performed a systematic review and meta-analysis of clinical trials comparing AngioJet versus CDT to assess the efficacy and safety of AngioJet thrombectomy. We systematically searched PubMed and Embase for clinical trials that published before November 1, 2020 and compared AngioJet thrombectomy and CDT in the treatment of LEDVT. We meta-analyzed effective rate of treatment, serious complications, PTS, Villalta score, duration of treatment and drug dose. AngioJet does not result in a significant difference in the effective rate (OR 1.00, CI 0.73-1.36, P = 0.98; I2= 0%) and complications (OR 1.16 CI 0.84-1.61, P = 0.36; I2= 39%) compare to CDT. And there was a statistically significant decrease in incidence of PTS (OR 0.58 CI 0.37-0.91, P = 0.02; I2= 0%) and Villalta score (OR −1.86 CI −3.49 to −0.24, P = 0.02; I2= 34%) for AngioJet compared to CDT. In addition, there was a statistically significant decrease in duration of the treatment (OR −2.45 CI −2.75 to −2.15, P < 0.0001; I2= 95%) and drug dose (OR −3.15 CI −3.38 to −2.93, P < 0.0001; I2= 98%) between AngioJet and CDT. AngioJet results in a low severity of PTS compared to CDT therapy. Moreover, the average duration of treatment and thrombolysis time was shorter in the AngioJet group compared to the CDT group. However, the AngioJet group was not significantly different in effective rate of treatment and serious complications compared to the CDT group. |
| Databáze: | OpenAIRE |
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