Evidence for the interaction of urapidil with 5-HT1A receptors in the brain leading to a decrease in blood pressure
| Autor: | Klaus-Dieter Beller, Karl H. Sanders, Norbert Kolassa |
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| Rok vydání: | 1989 |
| Předmět: |
Agonist
Medulla Oblongata medicine.medical_specialty business.industry medicine.drug_class Blood Pressure Vasodilation Urapidil Cardiovascular System Piperazines Endocrinology Blood pressure nervous system Receptors Serotonin Internal medicine Medulla oblongata Excitatory postsynaptic potential Animals Humans Medicine Serotonin Cardiology and Cardiovascular Medicine business Receptor |
| Zdroj: | The American Journal of Cardiology. 63:C36-C39 |
| ISSN: | 0002-9149 |
| Popis: | Current knowledge about the role of serotonin (5-HT) in central cardiovascular regulation is reviewed. Results from experiments with the 5-HT 1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) suggest that activation of somatodendritic 5-HT 1A receptors in the medulla oblongata decreases the firing of serotoninergic neurons and thus reduces their excitatory input to the sympathetic neurons in the intermediolateral cell column. As a consequence, blood pressure is reduced by 5-HT 1A receptor agonists. Urapidil is an antihypertensive drug that has a dual mode of action: peripheral α-adrenoceptor antagonism and interaction with 5-HT 1A receptors in the brain. This profile can adequately explain the vasodilation and lack of significant sympathetic activation observed during urapidil treatment. |
| Databáze: | OpenAIRE |
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