Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term nonprogressors
| Autor: | Lisa M. Fink, Anthony S. Fauci, Giuseppe Pantaleo, Jin Tao Zhou, G. Diego Miralles, David C. Montefiori, Miroslawa Bilska, Ji Ying Zhou |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Cytotoxicity Immunologic Male HIV Antigens Heterologous HIV Infections Complement Membrane Attack Complex HIV Antibodies Peripheral blood mononuclear cell Virus Neutralization Immunophenotyping Neutralization Tests HIV Seropositivity Immunology and Allergy Humans Antibody-dependent enhancement biology Middle Aged Virology CD4 Lymphocyte Count Titer Infectious Diseases biology.protein Disease Progression HIV-1 Leukocytes Mononuclear Female Viral disease Lymph Nodes Antibody |
| Zdroj: | The Journal of infectious diseases. 173(1) |
| ISSN: | 0022-1899 |
| Popis: | Serum antibodies from human immunodeficiency virus type 1 (HIV-1)-infected long-term non-progressors (LTNPs) and non-LTNPs were evaluated for virus neutralization and infection enhancement in vitro. Sera from LTNPs had higher average titers of neutralizing antibodies to HIV-1 strains III B and MN and more frequently neutralized primary isolates from progressors (14.9% vs. 1.3%, P =.002). Replication-competent HIV-1 was isolated from peripheral blood mononuclear cells and lymph nodes of 3 LTNPs. All viruses from LTNPs had a non-syncytium-inducing phenotype, were resistant to neutralization by autologous serum obtained at the time of virus isolation, and showed little evidence of a heightened sensitivity to neutralization by heterologous sera. Complement-mediated, antibody-dependent enhancement (C'-ADE) of HIV-1 IIIB and primary isolates was equally prevalent for sera from LTNPs and non-LTNPs. Results indicate that LTNPs produce vigorous serum antibody responses and that long-term nonprogression is not associated with homologous neutralization or the absence of C'-ADE. |
| Databáze: | OpenAIRE |
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