Dopamine autoreceptor reserve in vitro: possible role of dopamine D3 receptors
| Autor: | Cheryl Wiley Aretha, Matthew P. Galloway |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Alkylation Tetrahydronaphthalenes Dopamine Rats Sprague-Dawley Dopamine receptor D1 Dopamine receptor D3 Dopamine receptor D2 Internal medicine medicine Animals Drug Interactions Pharmacology Receptors Dopamine D2 Chemistry Colforsin Dopaminergic Receptors Dopamine D3 Olfactory Pathways Corpus Striatum Dihydroxyphenylalanine Rats Endocrinology Dopamine receptor Dopamine Agonists Potassium Quinolines Autoreceptor Dopamine Antagonists Endogenous agonist Adenylyl Cyclases medicine.drug |
| Zdroj: | European Journal of Pharmacology. 305:119-122 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(96)00142-2 |
| Popis: | Receptor alkylation in vivo with N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) decreased the potency, but not the efficacy, of the dopamine D3 receptor-preferring agonist 7-hydroxy-N, N-di-n-propyl-2-aminotetralin (7-OH-DPAT) at synthesis modulating dopamine autoreceptors in striatal and olfactory tubercle slices stimulated by 30 mM K+. In contrast, 7-OH-DPAT was ineffective in slices exposed to forskolin (10 microM). The results support the presence of autoreceptor reserve in vitro, and the partial involvement of dopamine D3 receptors in the autoregulation of dopamine synthesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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