Analgesics: synthesis of 1-dioxolanoalkylnormeperidines and 1-dioxanoalkylnormeperidines

Autor:	Douglas C. Kriesel, Ole Gisvold
Rok vydání:	1971
Předmět:	Analgesic effect Male Analgesics Meperidine Analgesic Pharmaceutical Science Dioxoles Pharmacology Dioxins Rats chemistry.chemical_compound Mice chemistry Dioxolane Animals Female
Zdroj:	Journal of pharmaceutical sciences. 60(8)
ISSN:	0022-3549
Popis:	The syntheses of the maleate salts of N-(2-methylene-1,3-dioxolano)normeperidine (II), N-(2-methylene-1,3-dioxano)normeperidine (III), N-(2-ethylene-1,3-dioxolano)normeperidine (IV), and N-(2-ethylene-1,3-dioxano)normeperidine (V) are reported. The dioxolane derivatives (II and IV) possessed analgesic activity, with II being slightly more active than meperidine. None of these compounds antagonized the analgesic effect of meperidine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509abf76d00e60879eea23ab20b9adc7 https://pubmed.ncbi.nlm.nih.gov/5127102 Zobrazit plný text záznamu Plný text