Use of thyroid hormones in hypothyroid and euthyroid patients: A 2020 THESIS questionnaire survey of members of the Danish Endocrine Society

Autor: Kamilla Ryom Riis, Enrico Papini, J. S. Frølich, Endre Nagy, Roberto Attanasio, L. Hegedüs, Petros Perros, Steen Joop Bonnema, Roberto Negro
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Pediatrics
medicine.medical_specialty
endocrine system
Thyroid Hormones
endocrine system diseases
Hormone Replacement Therapy
Endocrinology
Diabetes and Metabolism
Denmark
Drug Compounding
Levothyroxine
030209 endocrinology & metabolism
Danish
Liothyronine
03 medical and health sciences
0302 clinical medicine
Endocrinology
Hypothyroidism
Surveys and Questionnaires
medicine
Endocrine system
Humans
Euthyroid
Practice Patterns
Physicians'
Survey
Danish Endocrine Society
business.industry
Standard treatment
Patient Selection
Thyroid
language.human_language
Thyroxine
medicine.anatomical_structure
Endocrinologists
030220 oncology & carcinogenesis
language
Triiodothyronine
Original Article
Drug Therapy
Combination
Symptom Assessment
business
Euthyroidism
hormones
hormone substitutes
and hormone antagonists
medicine.drug
Hormone
Zdroj: Journal of Endocrinological Investigation
Riis, K R, Frølich, J S, Hegedüs, L, Negro, R, Attanasio, R, Nagy, E V, Papini, E, Perros, P & Bonnema, S J 2021, ' Use of thyroid hormones in hypothyroid and euthyroid patients : A 2020 THESIS questionnaire survey of members of the Danish Endocrine Society ', Journal of Endocrinological Investigation, vol. 44, no. 11, pp. 2435-2444 . https://doi.org/10.1007/s40618-021-01555-y
ISSN: 1720-8386
0391-4097
Popis: Purpose The standard treatment of hypothyroidism is levothyroxine (LT4), which is available as tablets or soft-gel capsules in Denmark. This study aimed to investigate Danish endocrinologists’ use of thyroid hormones in hypothyroid and euthyroid patients. Methods An e-mail with an invitation to participate in an online survey investigating practices about substitution with thyroid hormones was sent to all members of the Danish Endocrine Society (DES). Results Out of 488 eligible DES members, a total of 152 (31.2%) respondents were included in the analysis. The majority (94.1%) of responding DES members use LT4 as the treatment of choice. Other treatment options for hypothyroidism are also used, as 58.6% prescribe combination therapy with liothyronine (LT3) + LT4 in their clinical practice. LT4 + LT3 combination is preferred in patients with persistent symptoms of hypothyroidism despite biochemical euthyroidism on LT4 treatment. Over half of the respondents answered that thyroid hormone therapy is never indicated for euthyroid patients, but 42.1% will consider it for euthyroid infertile women with high antibody levels. In various conditions that could interfere with the absorption of LT4, most responding Danish endocrinologists prefer tablets and do not expect a significant difference when switching from one type of tablet formulation to another. Conclusion The treatment of choice for hypothyroidism is LT4. Combination therapy with LT4 + LT3 is considered for patients with persistent symptoms. Even in the presence of conditions affecting bioavailability, responding Danish endocrinologists prefer LT4 tablets rather than newer LT4 formulations, such as soft-gel capsules. Supplementary Information The online version contains supplementary material available at 10.1007/s40618-021-01555-y.
Databáze: OpenAIRE
Externí odkaz: