Pre-transplant shedding of BK virus in urine is unrelated to post-transplant viruria and viremia in kidney transplant recipients
| Autor: | Camila Malta Romano, Camila da Silva Bicalho, Maria Cristina Domingues da Silva Fink, Paulo Roberto Palma Urbano, Cláudio Sérgio Pannuti, Expedito José de Albuquerque Luna, Elias David-Neto, Luiz Hs Nali, Lígia Camera Pierrotti, Renato Reis Oliveira, D. S. R. David |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Adolescent Urinalysis viruses Viremia 030230 surgery Real-Time Polymerase Chain Reaction medicine.disease_cause Nephropathy Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors medicine Humans Prospective Studies Kidney transplantation Subclinical infection Polyomavirus Infections Transplantation medicine.diagnostic_test business.industry Incidence Graft Survival virus diseases Middle Aged medicine.disease Kidney Transplantation Virology Transplant Recipients Virus Shedding BK virus Tumor Virus Infections surgical procedures operative BK Virus DNA Viral Immunology Female 030211 gastroenterology & hepatology business REAÇÃO EM CADEIA POR POLIMERASE Brazil Follow-Up Studies |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | BK virus-(BKV) associated nephropathy (BKVN) is a major cause of allograft injury in kidney transplant recipients. In such patients, subclinical reactivation of latent BKV infection can occur in the pre-transplant period. The purpose of this study was to determine whether urinary BKV shedding in the immediate pre-transplant period is associated with a higher incidence of viruria and viremia during the first year after kidney transplantation. We examined urine samples from 34 kidney transplant recipients, using real-time quantitative polymerase chain reaction to detect BKV. Urine samples were obtained in the immediate pre-transplant period and during the first year after transplant on a monthly basis. If BKV viruria was detected, blood samples were collected and screened for BKV viremia. In the immediate pre-transplant period, we detected BKV viruria in 11 (32.3%) of the 34 recipients. During the first year after transplantation, we detected BKV viruria in all 34 patients and viremia in eight (23.5%). We found no correlation between pre-transplant viruria and post-transplant viruria or viremia (p = 0.2). Although reactivation of latent BKV infection in the pre-transplant period is fairly common among kidney transplant recipients, it is not a risk factor for post-transplant BKV viruria or viremia. |
| Databáze: | OpenAIRE |
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