Chemical Optimization of Artificial Metalloenzymes Based on the Biotin-Avidin Technology: (S)-Selective and Solvent-Tolerant Hydrogenation Catalysts via the Introduction of Chiral Amino Acid Spacers
| Autor: | Christophe Malan, Anita Ivanova, Myriem Skander, Thomas R. Ward |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Streptavidin
Phosphines Biotin chemistry.chemical_element Ligands Catalysis Rhodium chemistry.chemical_compound Organometallic Compounds Materials Chemistry Organic chemistry Amino Acids chemistry.chemical_classification Molecular Structure biology Metals and Alloys Stereoisomerism General Chemistry General Medicine Combinatorial chemistry Surfaces Coatings and Films Electronic Optical and Magnetic Materials Amino acid Solvent Enantiopure drug chemistry Solvents Ceramics and Composites biology.protein Hydrogenation Avidin |
| Zdroj: | ChemInform. 37 |
| ISSN: | 1522-2667 0931-7597 |
| DOI: | 10.1002/chin.200608167 |
| Popis: | Incorporation of biotinylated-[rhodium(diphosphine)]+ complexes, with enantiopure amino acid spacers, in streptavidin affords solvent-tolerant and selective artificial metalloenzymes: up to 91% ee (S) in the hydrogenation of N-protected dehydroamino acids. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text