Effect of Lipophilic lons on the Intramembrane Charge Movement and Intracellular Ca2+ Release in Fetal Mouse Skeletal Muscle Cells
| Autor: | T. Shimahara, R. Bournaud, I. Inoue |
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| Rok vydání: | 1997 |
| Předmět: |
Contraction (grammar)
Physiology chemistry.chemical_element Calcium Anilino Naphthalenesulfonates Calcium in biology Rhodamine 6G Mice chemistry.chemical_compound Onium Compounds Organophosphorus Compounds medicine Animals Coloring Agents Muscle Skeletal Cells Cultured Fluorescent Dyes Dose-Response Relationship Drug Rhodamines Skeletal muscle Depolarization Intracellular Membranes General Medicine Cell biology Spectrometry Fluorescence Membrane medicine.anatomical_structure chemistry Neuromuscular Depolarizing Agents Indicators and Reagents Intracellular Muscle Contraction |
| Zdroj: | The Japanese Journal of Physiology. 47:567-570 |
| ISSN: | 0021-521X |
| DOI: | 10.2170/jjphysiol.47.567 |
| Popis: | The effects of lipophilic ions on the intramembrane charge movement and intracellular calcium transient were studied using freshly dissociated skeletal muscle cells from mice fetuses. The lipophilic cations Rhodamine 6G and tetraphenylphosphonium (TPP) immobilized part of the intramembrane charge movement in a dose-dependent manner, and inhibited both calcium transient and contraction evoked by membrane depolarization. In contrast, the lipophilic anion 1-anilinonaphthalene-8-sulfonic acid (ANS) had no effect on intramembrane charge movement. We suggest that the lipophilic cations block the voltage-sensing mechanism for the excitation-contraction (E-C) coupling mechanism. |
| Databáze: | OpenAIRE |
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