PERIOPERATIVE HEPARIN-THERAPY INHIBITS LATE DEATH FROM METASTATIC CANCER

Autor:	Rcn Williamson, R Hedges, Vv Kakkar, AK Kakkar
Rok vydání:	1995
Předmět:	Oncology Cancer Research medicine.medical_specialty business.industry Warfarin Cancer Heparin Perioperative medicine.disease Malignancy Gastroenterology Pulmonary embolism Internal medicine Antithrombotic Carcinoma Medicine business medicine.drug
Zdroj:	International Journal of Oncology.
ISSN:	1791-2423 1019-6439
DOI:	10.3892/ijo.6.4.885
Popis:	Low-dose heparin prophylaxis reduces postoperative death from fatal pulmonary embolism and its long-term anti-cancer effect has now been assessed in a retrospective study of 1250 patients, 336 of whom (30%) underwent operation for cancer. There was a striking reduction in three year mortality amongst those patients who received low dose heparin compared to unteated controls (7.6% vs. 12.5%, P=0.005). Death from disseminated malignancy was halved (9.2% vs. 21.4%). The mechanism remains unclear, but may reflect either the antithrombotic actions of heparin or a direct antitumour cell effect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5093fe156c75d629fcb7aa14a93df924 https://doi.org/10.3892/ijo.6.4.885 Zobrazit plný text záznamu