Influence of long term silicone implantation on type II collagen induced arthritis in mice
| Autor: | Wooley Ph, Schaefer Cj, Lawrence Wd |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
inorganic chemicals
Pathology medicine.medical_specialty Immunology Type II collagen Silicones Connective tissue Arthritis complex mixtures Severity of Illness Index General Biochemistry Genetics and Molecular Biology Autoimmune Diseases chemistry.chemical_compound Mice Silicone Rheumatology medicine Immunology and Allergy Animals Autoantibodies business.industry Autoantibody technology industry and agriculture Prostheses and Implants medicine.disease Connective tissue disease Interleukin-10 Extended Report medicine.anatomical_structure chemistry Mice Inbred DBA Rheumatoid arthritis Silicone Elastomers Implant Collagen Sarcoma Experimental Interleukin-5 business |
| Zdroj: | Annals of the rheumatic diseases. 58(8) |
| ISSN: | 0003-4967 |
| Popis: | OBJECTIVES—The use of silicone implants in cosmetic and reconstructive surgery has been implicated in the development of autoimmune connective tissue diseases. Previous investigation of the influence of short-term silicone implantation using an experimental model of rheumatoid arthritis revealed no adverse influence upon disease despite the generation of autoantibodies against silicone bound proteins. This study was designed to examine the influence of long term implantation of different forms of silicone in collagen induced arthritis. METHODS—DBA/1 mice were surgically implanted with silicone elastomers, gel or oil nine months before immunisation with type II collagen emulsified in Freund's incomplete adjuvant. The incidence and severity of arthritis, antibodies to type II collagen, and serum cytokines were assessed and compared with sham implanted mice. Silicone implants were recovered, and autoantibodies to silicone bound proteins evaluated in arthritic and non-arthritic mice. RESULTS—Immunisation with CII/FIA resulted in a 30% arthritis incidence in sham implanted DBA/1 mice. Long term silicone implantation resulted in an increased incidence of arthritis, with a significant increase of 90% arthritis in animals implanted with silicone elastomers. Animals implanted with silicone elastomer also developed foreign body sarcomas during the study. Serum concentrations of interleukin 10 were increased in mice implanted with elastomers and immunised with CII/FIA, while interleukin 5 concentrations were significantly diminished in these mice. The production of autoantibodies to autologous silicone bound proteins, including anti-type I collagen antibody, was also attributed to the implantation of either silicone gel or silicone elastomer in type II collagen immunised animals. CONCLUSIONS—These data suggest that long term silicone implantation results in both the production of autoantibodies to connective tissue antigens and increased susceptibility to an experimental model of autoimmune disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|