Animal models for research on endometriosis
| Autor: | Hermawan Wibisono, Fuminori Taniguchi, Tasuku Harada, Yin Mon Khine |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty General Immunology and Microbiology business.industry Endometriosis Inflammation Disease Endometrium medicine.disease General Biochemistry Genetics and Molecular Biology Pathogenesis Disease Models Animal Mice medicine.anatomical_structure Animals Humans Medicine Female Uterine cavity medicine.symptom business |
| Zdroj: | Frontiers in Bioscience-Elite. 13:37 |
| ISSN: | 1945-0494 |
| DOI: | 10.2741/871 |
| Popis: | Endometriosis results from the aberrant growth of endometrium outside the inner lining of the uterine cavity. Similar to humans, the primates also menstruate and hence, the primate models constitute the gold standard for studying the pathogenesis and potential treatment for this disabling disease in women. Due to the expense in carrying endometriosis research in primates, other models have been developed for understanding the pathobiology and potential treatment of endometriosis. This includes explanting human endometrial tissues in athymic nude mice or using homologous mouse models. Here, we examine the murine models of endometriosis, the impact of forced induced inflammation on its development, similarities in the gene expression profile in the endometriotic tissues in such models with that seen in human endometriosis, and the drugs that are being used in such models as potential new treatment for endometriosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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