Forecasting the course of a heart failure in patients with a non-toxic goiter, accounting function of the thyroid gland
| Autor: | Tetiana O Chenchik, T. V. Lozyk, S. M. Pyvovar, I. Rudyk, Valentyna Galchinska |
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| Jazyk: | ukrajinština |
| Rok vydání: | 2020 |
| Předmět: |
серцева недостатність
medicine.medical_specialty Goiter lcsh:Medicine heart failure ризик Internal medicine medicine нетоксичний зоб In patient non-toxic goiter синдром «низького трийодтироніну» Subclinical infection risk перебіг Ejection fraction business.industry lcsh:R Thyroid прогнозування Low T3 Syndrome General Medicine medicine.disease medicine.anatomical_structure Ventricle Heart failure Cardiology prognosis business course |
| Zdroj: | ScienceRise: Medical Science, Vol 0, Iss 1 (34), Pp 4-9 (2019) |
| Popis: | The aim: to determine prognostic criteria for the course of heart failure in patients with non-toxic goiter. Material and methods.In the study 381 patients with heart failure on the background of post-infarction cardiosclerosis were included. Of these, 218 patients had non-toxic goiter. The levels of TSH, T3fr, T4fr, T3r, NT-proBNP were evaluated. An echocardioscopy, an ultrasound examination of the thyroid gland were conducted. We studied the course of heart failure for 2 years. Results. In patients with heart failure that occurs on the background of non-toxic goiter, compared to patients without it, a percentage of women is higher (respectively, 42.7 % versus 16.6 %, at p=0.001); they more often have IV NYHA FC (respectively – 13.3 %, against 5.5 %; p=0.043), 33.4 % higher level of NT-proBNP (p=0.001) and lower serum content of T3fr(2.30 pmol/L vs 2.76 pmol/L , at p=0.0001); higher end-diastolic dimension of the left ventricle by 3.8 % (p=0.006), end-diastolic volume by 8.9 % (p=0.006), end-systolic dimension by 5.4 % (p=0.002), end-systolic volume by 13.2 % (p=0.002), 6.5 % less ejection fraction (p=0.02); high frequency of the "low T3" syndrome (odd ratio (OR)=7.94 (4.04–15.61), p=0.0001) and subclinical hypothyroidism (OR=5.21 (1.52–17.90), p=0.004), a high risk of re-hospitalization (OR=3.037 (1.85–4.99), p=0.0001) and a composite endpoint (OR=2.53 (1.60–3.995), p=0.001). Patients with non-toxic goiter without the "low T3" syndrome did not have a significant difference in the course of heart failure. In the group of patients with heart failure that flew on the background of non-toxic goiter and “low T3“ syndrome, there were high risks of re-hospitalization (OR=6.82 (1.38–33.72), p=0.022) and achievement of the composite endpoint (OR=4.76 (1.17–19.41), p=0.047) during 2 years of observation. Conclusions. In heart failure with non-toxic goiter, with the "low T3" syndrome, it is possible to predict an unfavorable decease course during 2 years of observation: a high risk of re-hospitalization and composite endpoint |
| Databáze: | OpenAIRE |
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