Acute and Chronic Altitude-Induced Cognitive Dysfunction in Children and Adolescents
| Autor: | Carlos Salinas, Emrush Rexhaj, Yves Allemann, Stefano F. Rimoldi, Hervé Duplain, Alejandro Ayaviri, Mercedes Villena, Claudio Sartori, Sébastien Urben, Urs Scherrer, Catherine Romero, Joël Billieux |
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| Přispěvatelé: | UCL - SSH/IPSY - Psychological Sciences Research Institute |
| Rok vydání: | 2015 |
| Předmět: |
Male
Cognition Disorders/diagnosis medicine.medical_specialty Cognition Disorders/etiology Adolescent Trail Making Test Cognition Disorders/physiopathology Altitude Sickness Neuropsychological Tests Audiology Spatial memory 050105 experimental psychology 03 medical and health sciences Cognition 0302 clinical medicine Altitude Humans Medicine 0501 psychology and cognitive sciences Altitude Sickness/complications 610 Medicine & health Child Hypoxia Episodic memory Altitude sickness Cognition/physiology Memory Disorders business.industry Working memory 05 social sciences Effects of high altitude on humans Hypoxia (medical) medicine.disease Acute Disease Chronic Disease Pediatrics Perinatology and Child Health Physical therapy Anoxia/complications 570 Life sciences biology Female medicine.symptom Cognition Disorders business 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Pediatrics, Vol. 169, p. 238-243 (2016) The Journal of Pediatrics, vol. 169, pp. 238-243 |
| Popis: | Objective To assess whether exposure to high altitude induces cognitive dysfunction in young healthy European children and adolescents during acute, short-term exposure to an altitude of 3450 m and in an age-matched European population permanently living at this altitude. Study design We tested executive function (inhibition, shifting, and working memory), memory (verbal, short-term visuospatial, and verbal episodic memory), and speed processing ability in: (1) 48 healthy nonacclimatized European children and adolescents, 24 hours after arrival at high altitude and 3 months after return to low altitude; (2) 21 matched European subjects permanently living at high altitude; and (3) a matched control group tested twice at low altitude. Results Short-term hypoxia significantly impaired all but 2 (visuospatial memory and processing speed) of the neuropsychological abilities that were tested. These impairments were even more severe in the children permanently living at high altitude. Three months after return to low altitude, the neuropsychological performances significantly improved and were comparable with those observed in the control group tested only at low altitude. Conclusions Acute short-term exposure to an altitude at which major tourist destinations are located induces marked executive and memory deficits in healthy children. These deficits are equally marked or more severe in children permanently living at high altitude and are expected to impair their learning abilities. |
| Databáze: | OpenAIRE |
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