Cyclic Triimidazoles as Stabilizers for Gene Promoter and Human Telomeric DNA G‐Quadruplexes

Autor:	Daniele Malpicci, Stefano Andolina, Stefano Di Ciolo, Elena Lucenti, Elena Cariati, Simona Marzano, Bruno Pagano, Jussara Amato, Antonio Randazzo, Clelia Giannini
Přispěvatelé:	Malpicci, D., Andolina, S., Di Ciolo, S., Lucenti, E., Cariati, E., Marzano, S., Pagano, B., Amato, J., Randazzo, A., Giannini, C.
Rok vydání:	2022
Předmět:	G-quadruplex Aminoguanidine Organic Chemistry Cyclic triimidazole Ligand design N-methylated pyridine Settore CHIM/06 - Chimica Organica Physical and Theoretical Chemistry
Zdroj:	European Journal of Organic Chemistry. 2022
ISSN:	1099-0690 1434-193X
DOI:	10.1002/ejoc.202200718
Popis:	The synthesis and characterization of a small series of cyclic triimidazole derivatives functionalized with methylated pyridine or guanidine moieties is reported. These compounds were tested for their ability to bind to G-quadruplexes from both telomeric and oncogene promoter sequences. Some of them exhibited high affinity and effective G-quadruplex-stabilizing properties. Overall, these compounds may represent useful leads for developing more potent and selective analogues.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50910476bc3783784048c2f3e281babe https://doi.org/10.1002/ejoc.202200718 Zobrazit plný text záznamu