Implementation of a molecular tumor board at a regional level to improve access to targeted therapy

Autor: Jean-Philippe Metges, Thierry Lesimple, Solène-Florence Kammerer-Jacquet, Alexandra Lespagnol, Florent Denoual, Lise Boussemart, Julien Edeline, Edouard Le Gall, Boris Campillo-Gimenez, Ingrid Felten-Vinot, Cédric le Marechal, Héloïse Bourien, Romain Corre, Marie de Tayrac, Jean Mosser, Marie-Dominique Galibert
Přispěvatelé: Centre Eugène Marquis (CRLCC), CHU Pontchaillou [Rennes], Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Institut de Génétique et Développement de Rennes (IGDR), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Service de Pathologie [Rennes] = Pathology [Rennes], Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Rok vydání: 2020
Předmět:
Adult
Male
0301 basic medicine
Oncology
medicine.medical_specialty
Adolescent
medicine.medical_treatment
[SDV.CAN]Life Sciences [q-bio]/Cancer
Molecular Targeted Therapies
Molecular tumor board
Medical Oncology
Health Services Accessibility
Targeted therapy
Young Adult
03 medical and health sciences
0302 clinical medicine
Surgical oncology
Next generation sequencing
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Genomics [q-bio.GN]
Neoplasms
Internal medicine
medicine
Drug approval
Humans
Tumor board
Molecular Targeted Therapy
Precision Medicine
Medical prescription
Child
Aged
Retrospective Studies
Aged
80 and over
business.industry
High-Throughput Nucleotide Sequencing
Hematology
General Medicine
Middle Aged
3. Good health
Clinical trial
Treatment Outcome
030104 developmental biology
Drug Resistance
Neoplasm
030220 oncology & carcinogenesis
Female
Surgery
Personalized medicine
business
Zdroj: International Journal of Clinical Oncology
International Journal of Clinical Oncology, Springer Verlag, 2020, 25 (7), pp.1234-1241. ⟨10.1007/s10147-020-01661-6⟩
International Journal of Clinical Oncology, 2020, 25 (7), pp.1234-1241. ⟨10.1007/s10147-020-01661-6⟩
ISSN: 1437-7772
1341-9625
DOI: 10.1007/s10147-020-01661-6
Popis: International audience; Background With the development of precision oncology, Molecular Tumor Boards (MTB) are developing in many institutions. However, the implementation of MTB in routine clinical practice has still not been thoroughly studied. Material and methods Since the first drugs approved for targeted therapies, patient tumor samples were centralized to genomic testing platforms. In our institution, all tumor samples have been analyzed since 2014 by Next Generation Sequencing (NGS). In 2015, we established a regional MTB to discuss patient cases with 1 or more alterations identified by NGS, in genes different from those related to drug approval. We conducted a retrospective comparative analysis to study whether our MTB increased the prescriptions of Molecular Targeted Therapies (MTT) and the inclusions of patients in clinical trials with MTT, in comparison with patients with available NGS data but no MTB discussion. Results In 2014, 86 patients had UGA, but the results were not available to clinicians and not discussed in MTB. During the years 2015 and 2016, 113 patients with an UGA (unreferenced genomic alteration) were discussed in MTB. No patients with an UGA were included in 2014 in a clinical trial, versus 2 (2%) in 2015-2016. 13 patients with an UGA (12%) were treated in 2015-2016 with a MTT whereas in 2014, no patient (p = 0.001). Conclusions In this retrospective analysis, we showed that the association of large-scale genomic testing and MTB was feasible, and could increase the prescription of MTT. However, in routine clinical practice, the majority of patients with UGA still do not have access to MTT.
Databáze: OpenAIRE
Externí odkaz: