Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias

Autor:	Ronald Eugene White, Laurent Djandjighian, Andrew J. Fluxe, John Michael Janusz, Shengde Wu, Steven J. Hodson, James M. Ridgeway, Benjamin E. Blass, Gina M. Fadayel, Keith R. Coburn, Jackson Christopher M, Michael Murawsky
Rok vydání:	2006
Předmět:	medicine.medical_specialty Clinical Biochemistry Thiazolidine Pharmaceutical Science complex mixtures Biochemistry chemistry.chemical_compound Kv1.5 Potassium Channel Internal medicine Drug Discovery Atrial Fibrillation medicine Potassium Channel Blockers Animals Humans natural sciences cardiovascular diseases Molecular Biology Biological evaluation Organic Chemistry P wave Atrial fibrillation Atrial arrhythmias medicine.disease Potassium channel Blockade Rats nervous system chemistry Atrial Flutter cardiovascular system Cardiology Molecular Medicine Thiazolidines Anti-Arrhythmia Agents Atrial flutter
Zdroj:	Bioorganicmedicinal chemistry letters. 17(1)
ISSN:	0960-894X
Popis:	Blockade of the Kv1.5 ion channel is a potentially atrial-selective avenue for the treatment of atrial fibrillation and atrial flutter. The development and biological evaluation of a series of thiazolidine-based blockers of Kv1.5 is described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508dd9d9cdd8307bb20a62cf10dcf507 https://pubmed.ncbi.nlm.nih.gov/17095219 Zobrazit plný text záznamu Full Text from ScienceDirect