Liver steatosis (LS) evaluated through chemical-shift magnetic resonance imaging liver enzymes in morbid obesity; effect of weight loss obtained with intragastric balloon gastric banding
Autor: | Annamaria Veronelli, Marco Cappelletti, Giancarlo Micheletto, Antonio E. Pontiroli, Carlo Pozzato, Laura Folini, A. Benetti, Enzo Masci |
---|---|
Rok vydání: | 2013 |
Předmět: |
Adult
Male medicine.medical_specialty Waist Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Bariatric Surgery digestive system Young Adult chemistry.chemical_compound Endocrinology Insulin resistance Weight loss Diabetes mellitus Internal medicine Weight Loss Internal Medicine Humans Insulin Medicine Aspartate Aminotransferases Aged Gastric Balloon business.industry Alanine Transaminase gamma-Glutamyltransferase General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Obesity digestive system diseases Obesity Morbid Fatty Liver Radiography Treatment Outcome Liver Basal (medicine) chemistry Female Glycated hemoglobin medicine.symptom business |
Zdroj: | Acta Diabetologica. 51:361-368 |
ISSN: | 1432-5233 0940-5429 |
Popis: | The aim of this study was to evaluate in morbid obesity clinical and metabolic effects related to weight loss on liver steatosis (LS), measured through chemical-shift magnetic resonance imaging (MRI) and liver enzymes. Forty obese subjects (8 M/32 W; BMI 42.8 ± 7.12 kg/m(2), mean ± SD) were evaluated for LS through ultrasound (US-LS), chemical-shift MRI (MRI-LS), liver enzymes [aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyltransferase (GGT), alkaline phosphatase (ALP)], anthropometric parameters [weight, BMI, waist circumference (WC)], lipids, insulin, insulin resistance (HOMA-IR), glycated hemoglobin (HbA1c), oral glucose tolerance test, and body composition [fat mass (FM) and fat-free mass (FFM) at bio-impedance analysis (BIA)]. Anthropometric measures, MRI-LS, BIA, and biochemical parameters were reevaluated 6 months later in 18 subjects undergoing restrictive bariatric approach, i.e., intragastric balloon (BIB, n = 13) or gastric banding (LAGB, n = 5), and in 13 subjects receiving hypocaloric diet. At baseline, US-LS correlates only with MRI-LS, and the latter correlates with ALT, AST, and GGT. After 6 months, subjects undergoing BIB or LAGB had significant changes of BMI, weight, WC, ALT, AST, GGT, ALP, HbA1c, insulin, HOMA-IR, FM, FFM, and MRI-LS. Diet-treated obese subjects had no significant change of any parameter under study; change of BMI, fat mass, and fat-free mass was significantly greater in LAGB/BIB subjects than in diet-treated subjects. Change of MRI-LS showed a significant correlation with changes in weight, BMI, WC, GGT, ALP, and basal MRI-LS. Significant weight loss after BIB or LAGB is associated with decrease in chemical-shift MRI-LS and with reduction in liver enzymes; chemical-shift MRI and liver enzymes allow monitoring of LS in follow-up studies. |
Databáze: | OpenAIRE |
Externí odkaz: |