| Autor: |
Helena M. Earl, Paul P.D. Pharoah, Carlos Caldas, Christopher J. Poole, Janet A. Dunn, Sarah J. Bowden, Linda Jones, Russell Burns, Louise Hiller, Anne-Laure Vallier, Richard Hardy, Susan Ingle, Jonathan Tyrer, Leila Dorling, Qi Guo, Jean E. Abraham |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1078-0432.22455335 |
| Popis: |
PDF file - 237KB, Supplementary Table 1: Published Studies of Putative Functional SNPs Supplementary Table 2a: Drug Regimens and Doses of Taxanes by Study Supplementary Table 2b: Comparison of Toxicity grades/rates by recruiting trial in PGSNPS included in Taxane Related Sensory Neuropathy Study Supplementary Table 3: PGSNPS Taxane Treated Patient Characteristics Supplementary Table 4: All Putative Functional SNPs Replicated in the PGSNPS dataset (phenotype: cumulative dose to TRSN) Supplementary Table 5: All Putative Functional SNPs Replicated in the PGSNPS dataset (phenotype: maximum TRSN) Supplementary Figure 1: Percentage of Patients with TRSN ≥ grade 2 by genotype, for three statistically significant SNPs that were genotyped in PGSNPS (maximum TRSN) Supplementary Figures 2a-c: Kaplan-Meier curves Kaplan-Meier curves: Shows for each SNP, by genotype, the probability of TRSN grade 0-1 (i.e., the probability of not experiencing moderate/severe TRSN) as the cumulative dose increases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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