AgRP neurons: Regulators of feeding, energy expenditure, and behavior
| Autor: | Gregory J. Morton, Jennifer D. Deem, Chelsea L. Faber |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Neurons
Prioritization Food intake digestive oral and skin physiology Arcuate Nucleus of Hypothalamus Cell Biology Biochemistry Article Energy homeostasis nervous system Energy expenditure Arcuate nucleus Biological neural network Agouti-Related Protein Energy Metabolism Psychology Molecular Biology Sensory cue Neuronal population Neuroscience |
| Zdroj: | FEBS J |
| ISSN: | 1742-4658 1742-464X |
| DOI: | 10.1111/febs.16176 |
| Popis: | Neurons in the hypothalamic arcuate nucleus (ARC) that express agouti-related peptide (AgRP) govern a critical aspect of survival: the drive to eat. Equally important to survival is the timing at which food is consumed - seeking or eating food to alleviate hunger in the face of a more pressing threat, like the risk of predation, is clearly maladaptive. To ensure optimal prioritization of behaviors within a given environment, therefore, AgRP neurons must integrate signals of internal need states with contextual environmental cues. In this State-of-the-Art review, we highlight recent advances that extend our understanding of AgRP neurons, including the neural circuits they engage to regulate feeding, energy expenditure, and behavior. We also discuss key findings that illustrate how both classical feedback and anticipatory feed-forward signals regulate this neuronal population and how the integration of these signals may be disrupted in states of energy excess. Finally, we examine both technical and conceptual challenges facing the field moving forward. |
| Databáze: | OpenAIRE |
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