Distribution in the brain and possible neuroprotective effects of intranasally delivered multi-walled carbon nanotubes
| Autor: | Massimo Marcaccio, Marzia Soligo, Susanna Bosi, Luigi Manni, Fausto Maria Felsani, Elena Pellizzoni, Tatiana Da Ros, S. Fiorito, Stefano Bruni, Jacopo Isopi |
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| Přispěvatelé: | Soligo, M., Felsani, F. M., Da Ros, T., Bosi, S., Pellizzoni, E., Bruni, S., Isopi, J., Marcaccio, M., Manni, L., Fiorito, S., Soligo M., Felsani F.M., Da Ros T., Bosi S., Pellizzoni E., Bruni S., Isopi J., Marcaccio M., Manni L., Fiorito S. |
| Rok vydání: | 2021 |
| Předmět: |
Nervous system
brain Carbon nanotubes Bioengineering 02 engineering and technology Carbon nanotube Neurodegenerative disease Neuroprotection law.invention 03 medical and health sciences Electric conductivity 0302 clinical medicine law Neurotrophic factors medicine Distribution (pharmacology) proNGF rat General Materials Science Modulation Chemistry MWCNT Medical application General Engineering General Chemistry 021001 nanoscience & nanotechnology mNGF Atomic and Molecular Physics and Optics Nanotube medicine.anatomical_structure Nerve growth factor Neurology Gliosis Nasal administration medicine.symptom 0210 nano-technology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nanoscale advances Online (2020). doi:10.1039/D0NA00869A info:cnr-pdr/source/autori:Marzia Soligo 1, Fausto Maria Felsani 1, Tatiana Da Ros 2, Susanna Bosi 2, Elena Pellizzoni 2, Stefano Bruni 3, Jacopo Isopi 4, Massimo Marcaccio 4, Luigi Manni 1 and Silvana Fiorito 1/titolo:Distribution in the brain and possible neuroprotective effects of intranasally delivered multi-walled carbon nanotubes/doi:10.1039%2FD0NA00869A/rivista:Nanoscale advances Online/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume |
| ISSN: | 2516-0230 |
| Popis: | Carbon nanotubes (CNTs) are currently under active investigation for their use in several biomedical applications, especially in neurological diseases and nervous system injury due to their electrochemical properties. Nowadays, no CNT-based therapeutic products for internal use appear to be close to the market, due to the still limited knowledge on their fate after delivery to living organisms and, in particular, on their toxicological profile. The purpose of the present work was to address the distribution in the brain parenchyma of two intranasally delivered MWCNTs (MWCNTs 1 and a-MWCNTs 2), different from each other, the first being non electroconductive while the second results in being electroconductive. After intranasal delivery, the presence of CNTs was investigated in several brain areas, discriminating the specific cell types involved in the CNT uptake. We also aimed to verify the neuroprotective potential of the two types of CNTs, delivering them in rats affected by early diabetic encephalopathy and analysing the modulation of nerve growth factor metabolism and the effects of CNTs on the neuronal and glial phenotypes. Our findings showed that both CNT types, when intranasally delivered, reached numerous brain areas and, in particular, the limbic area that plays a crucial role in the development and progression of major neurodegenerative diseases. Furthermore, we demonstrated that electroconductive MWCNTs were able to exert neuroprotective effects through the modulation of a key neurotrophic factor and probably the improvement of neurodegeneration-related gliosis. |
| Databáze: | OpenAIRE |
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