Effect of hypercortisolism on bone mineral density and bone metabolism: A potential protective effect of adrenocorticotropic hormone in patients with Cushing’s disease

Autor: Kunling Wang, Tiehong Zhu, Qing He, Baoping Wang, Chonggui Zhu, Jin Cui, Wei Liu, Zhi-hong Gao, Shaofang Tang, Chen-lin Dai, Hui-Qi Qu, Fengao Li, Fangqiu Zheng, Zhongshu Ma, Menghua Yuan, Hongwei Jia, Hongyan Wei, Mei Zhu, Weihong Guo
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Medicine (General)
Hydrocortisone
Osteoporosis
Gene Expression
Osteoclasts
Disease
Biochemistry
Bone remodeling
Absorptiometry
Photon
0302 clinical medicine
Bone Density
Cushing Syndrome
Bone mineral
Lumbar Vertebrae
Clinical Report
Femur Neck
General Medicine
Middle Aged
Cushing’s disease
adrenal-dependent Cushing’s syndrome
Female
Procollagen
Adult
musculoskeletal diseases
medicine.medical_specialty
Osteocalcin
030209 endocrinology & metabolism
Adrenocorticotropic hormone
Bone and Bones
Collagen Type I
03 medical and health sciences
R5-920
Adrenocorticotropic Hormone
Internal medicine
Bone mineral density
medicine
Humans
In patient
Pituitary ACTH Hypersecretion
Retrospective Studies
Osteoblasts
hypercortisolism
business.industry
Biochemistry (medical)
Cell Biology
Cushing's disease
medicine.disease
osteoporosis
Peptide Fragments
030104 developmental biology
Endocrinology
Case-Control Studies
Peptides
business
bone turnover markers
Zdroj: Journal of International Medical Research, Vol 46 (2018)
The Journal of International Medical Research
ISSN: 1473-2300
0300-0605
DOI: 10.1177/0300060517725660
Popis: Objective To investigate the effects of Cushing’s disease (CD) and adrenal-dependent Cushing’s syndrome (ACS) on bone mineral density (BMD) and bone metabolism. Methods Data were retrospectively collected for 55 patients with hypercortisolism (CD, n = 34; ACS n = 21) from January 1997 to June 2014. BMD was examined in all patients, and bone turnover markers were tested in some patients. Healthy controls (n = 18) were also recruited. Results The lumbar spine and femoral neck BMD were significantly lower in the ACS and CD groups than in the control group. Lumbar BMD was significantly lower in the ACS than CD group. The collagen breakdown product (CTX) concentrations were significantly higher while the osteocalcin and procollagen type I N-terminal propeptide (PINP) concentrations were significantly lower in the ACS and CD groups than in the control group. The PINP concentration was significantly lower while the CTX concentration was significantly higher in the ACS than CD group. In the CD group only, lumbar BMD and serum adrenocorticotropic hormone had a significant positive correlation. Conclusions Bone turnover markers indicated suppressed osteoblast and enhanced osteoclast activities. PINP and CTX changes might indicate bone mass deterioration. Adrenocorticotropic hormone might be protective for lumbar BMD in patients with CD.
Databáze: OpenAIRE
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