Resolution of Whipple Disease–Induced Pulmonary Hypertension Following Antibiotic Therapy
| Autor: | Lisa Ganjhu, Anca Georgescu, Nebras Zeizafoun, Sumedh S. Hoskote, Bruce Polsky |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Hypertension Pulmonary Gastroenterology Muscle hypertrophy Tropheryma whipplei Internal medicine Antibiotic therapy medicine Humans Endocarditis Pharmacology (medical) Pharmacology biology business.industry Whipple Disease Clinical course General Medicine Middle Aged biology.organism_classification medicine.disease Pulmonary hypertension Anti-Bacterial Agents Ceftriaxone Female business medicine.drug |
| Zdroj: | American Journal of Therapeutics. 21:e143-e147 |
| ISSN: | 1075-2765 |
| DOI: | 10.1097/mjt.0b013e3182691cdc |
| Popis: | Whipple disease is a disorder caused by Tropheryma whipplei, a ubiquitous Gram-positive bacillus. In addition to gastrointestinal manifestations, many other systems may be involved in Whipple disease. Pulmonary hypertension (PH) is a rare manifestation of Whipple disease, and its clinical course is not well established. We report a case of a 45-year-old woman who presented with typical gastrointestinal manifestations of Whipple disease, which was diagnosed by duodenal biopsy. She was also noted to have elevated pulmonary arterial pressures on transthoracic echocardiography. There was no evidence of left-sided valvular disease, hypertrophy, or dyskinesis, and there was no evidence of endocarditis. The patient was started on intravenous ceftriaxone for 6 weeks and then transitioned to oral trimethoprim-sulfamethoxazole for a year. The patient demonstrated clinical improvement, endoscopic and histologic improvement, and also resolution of PH. This is the third reported case of PH that is convincingly secondary to Whipple disease that resolved after appropriate antibiotic therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|