Subclinical Choroidal Inflammation Revealed by Indocyanine Green Angiography in Tubulointerstitial Nephritis and Uveitis Syndrome
| Autor: | D Makhoul, Lisa Scifo, Casper de Jong, Ksenija Lolin Sekelj, Francois Willermain, Monalisa Zampieri, Agnieszka Pozdzik, Laurence Postelmans |
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| Rok vydání: | 2021 |
| Předmět: |
Indocyanine Green
medicine.medical_specialty Angiotensins Urinary system medicine.medical_treatment Tubulointerstitial nephritis and uveitis Methylprednisolone Uveitis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Adrenal Cortex Hormones Rheumatoid Factor Ophthalmology Immunology and Allergy Medicine Rheumatoid factor Humans Fluorescein Angiography Subclinical infection Retrospective Studies 030203 arthritis & rheumatology Inflammation medicine.diagnostic_test business.industry Retinal Immunosuppression Fluorescein angiography medicine.disease chemistry Tin 030221 ophthalmology & optometry Nephritis Interstitial business Immunosuppressive Agents |
| Zdroj: | Ocular immunology and inflammation. 30(5) |
| ISSN: | 1744-5078 |
| Popis: | Purpose: To describe subclinical chorioretinal lesions revealed by indocyanine green angiography (ICGA) and their evolution under systemic treatment in tubulointerstitial nephritis and uveitis (TINU) patients.Methods: Retrospective case series of three patients with TINU syndrome. Choroidal and retinal involvement were assessed by fluorescein angiography (FA) and ICGA.Results: Three patients were analyzed. FA demonstrated hot disc, associated in two cases with retinal vascular leakage, and ICGA revealed subclinical chorioretinal dots in all three cases. Given the presence of posterior uveitis and deterioration of kidney function, asystemic treatment by oral methylprednisolone was started. Persistence of retinal and choroidal inflammations under systemic corticosteroids required association with immunosuppressive agent to control the disease activityConclusion: Multimodal imaging and more precisely ICGA is useful to assess subclinical choroidal inflammation and monitor treatment response in TINU syndrome. Immunosuppression needs to be revised and adapted when uveitis and/or kidney function are unresponsive to systemic steroidsAbbreviations: TINU: tubulointerstitial nephritis and uveitis; TIN: tubulointerstitial nephritis; ACE: angiotensin-converting enzyme; RF: rheumatoid factor; Uβ2M: urinary β-2microglobulin; AMPPE: acute multifocal placoid pigment epitheliopathy; FA: fluorescein angiography; ICGA: indocyanine green angiography; CT: computed tomography. |
| Databáze: | OpenAIRE |
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