Serum Levels of Thyroid-Stimulating Hormone Receptor Antibodies during IFN-alpha2a Treatment of Chronic Hepatitis C
| Autor: | Akira Kinugasa, Hiromasa Kamimoto, Takashi Miyoshi, Miki Fujimoto, Masaaki Wada, Koji Sawada, Takashi Shimoyama |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty endocrine system diseases Immunology Interferon alpha-2 Antiviral Agents Group A Group B Chronic hepatitis Virology Internal medicine medicine Humans Receptor Aged biology business.industry Thyroid Interferon-alpha Receptors Thyrotropin Cell Biology Hepatitis C Antibodies Hepatitis C Chronic Middle Aged Recombinant Proteins Anti-thyroid autoantibodies Endocrinology medicine.anatomical_structure biology.protein Female Antibody business Hormone |
| Zdroj: | Journal of Interferon & Cytokine Research. 19:85-88 |
| ISSN: | 1557-7465 1079-9907 |
| DOI: | 10.1089/107999099314450 |
| Popis: | Twenty chronic hepatitis C patients with baseline levels of thyroid hormones, antithyroglobulin, and antimicrosomal antibodies within the normal range were monitored by thyroid testing during a 26-week treatment with interferon-alpha2a (IFN-alpha2a). The present study was aimed at retrospectively analyzing thyroid-stimulating hormone (TSH) receptor antibodies, employing stored serum samples obtained from these patients at baseline, at 12 weeks, and at the end of IFN-alpha2a treatment. Ten patients (group A) received IFN-alpha2a at a total dose of 474 million units (MU), and 10 patients (group B) at a total dose of 774 MU. None of the patients produced antithyroglobulin and antimicrosomal antibodies. Two patients in group A exhibited elevated TSH levels without free thyroid hormone alterations while on the treatment. At baseline, 1 patient in group A had a positive TSH binding inhibitory immunoglobulin, and 1 patient in group B was positive for thyroid-stimulating antibody at the end of treatment. Both patients remained euthyroid throughout the treatment. Treatment with IFN-alpha2a may infrequently induce the production of TSH receptor antibodies in chronic hepatitis C patients provided preexisting autoimmune thyroid disease is precluded. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|