Molecular genetic approaches to the targeted suppression of neuronal activity
| Autor: | Benjamin H. White, Haig Keshishian, Thomas Osterwalder |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Neurons
Nervous system Potassium Channels Agricultural and Biological Sciences(all) Biochemistry Genetics and Molecular Biology(all) Biology General Biochemistry Genetics and Molecular Biology Drosophila melanogaster medicine.anatomical_structure In vivo Synapses medicine Animals Premovement neuronal activity General Agricultural and Biological Sciences Neuroscience Function (biology) |
| Zdroj: | Current Biology. 11:R1041-R1053 |
| ISSN: | 0960-9822 |
| DOI: | 10.1016/s0960-9822(01)00621-2 |
| Popis: | Understanding how the diverse cells of the nervous system generate sensations, memories and behaviors is a profound challenge. This is because the activity of most neurons cannot easily be monitored or individually manipulated in vivo . As a result, it has been difficult to determine how different neurons contribute to nervous system function, even in simple organisms like Drosophila . Recent advances promise to change this situation by supplying molecular genetic tools for modulating neuronal activity that can be deployed in a spatially and temporally restricted fashion. In some cases, targeted groups of neurons can be ‘switched off' and back ‘on' at will in living, behaving animals. |
| Databáze: | OpenAIRE |
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