Effect of testosterone and a nutritional supplement, alone and in combination, on hospital admissions in undernourished older men and women
| Autor: | Kamilia Tai, Angela J. Hammond, John E. Morley, Damien P Belobrajdic, Richard Y. T. Chen, John B F Field, Michael Horowitz, Ian Chapman, Renuka Visvanathan |
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| Rok vydání: | 2009 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Nutritional Supplementation Medicine (miscellaneous) Hematocrit law.invention Electrolytes Quality of life Randomized controlled trial Weight loss law Internal medicine medicine Humans Testosterone Aged Nutrition and Dietetics medicine.diagnostic_test business.industry Malnutrition Age Factors Testosterone (patch) Prostate-Specific Antigen medicine.disease Surgery Hospitalization C-Reactive Protein Dietary Supplements Quality of Life Female medicine.symptom business Body mass index |
| Zdroj: | The American journal of clinical nutrition. 89(3) |
| ISSN: | 1938-3207 |
| Popis: | Background: In older people, undernutrition is associated with increased hospitalization rates and mortality. Because weight loss in older people often reflects a disproportionate reduction of skeletal muscle, anabolic treatments may be beneficial. Objective: Our aim was to evaluate the hypothesis that testosterone treatment and a nutritional supplement have additive benefits. Design: Oral testosterone undecanoate (40 mg daily for women, 80 mg twice daily for men) and an oral nutritional supplement (475 kcal/d) were administered, alone or co mbined, for 1yt o 49 communitydwelling, undernourished people [Mini Nutritional Assessment score ,24 and low body weight (body mass index, in kg/m 2 : ,22) or recent weight loss (.7.5% over 3 mo)] aged .65 y (mean age: 77 y; 26 women and 23 men). Hospital admissions and other variables were assessed. Results: In subjects receiving combined testosterone and nutritional supplements (n ¼ 11), there were no hospital admissions, whereas there were 9 admissions (2 elective) in 13 subjects in the no-treatment group, 4 in the testosterone-treated group (n ¼ 12), and 5 in the supplement-treated group (n ¼ 13); P ¼ 0.06 with no-treatment compared with combined treatment. When compared with the notreatment group, the combined-treatment group had significantly fewer subjects admitted to hospital (0 compared with 5, P ¼ 0.03), fewer days in hospital (0 compared with 74, P ¼ 0.041), and a longer time to hospital admission (P ¼ 0.017). Conclusions: In undernourished older people, combined treatment with testosterone and nutritional supplementation reduced the number of people hospitalized and the duration of hospital admissions, which are important endpoints in this group. Larger, confirmatory studies are now needed. This trial was registered before commencement at clinical trials.gov as NCT00117000. Am J Clin Nutr 2009;89:880‐9. |
| Databáze: | OpenAIRE |
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