Neonatal Prefrontal Inactivation Results in Reversed Dopaminergic Responses in the Shell Subregion of the Nucleus Accumbens to NMDA Antagonists
| Autor: | Alain Louilot, Francisca Meyer, Emmanuelle Tagliabue, Yusuf Usun, Tiphaine Pouvreau, Séverine Eybrard |
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| Přispěvatelé: | Faculty of Medicine-ULP |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Physiology Dopamine Cognitive Neuroscience [SDV]Life Sciences [q-bio] [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Prefrontal Cortex Tetrodotoxin Nucleus accumbens Biochemistry Nucleus Accumbens Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine medicine Animals [CHIM]Chemical Sciences Anesthetics Local Receptor Prefrontal cortex ComputingMilieux_MISCELLANEOUS Analysis of Variance Molecular Animal Physiology Dopaminergic Cell Biology General Medicine [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences medicine.disease Rats Dizocilpine 030104 developmental biology Animals Newborn nervous system Schizophrenia [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology NMDA receptor Ketamine [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Dizocilpine Maleate Psychology [CHIM.OTHE]Chemical Sciences/Other Excitatory Amino Acid Antagonists Neuroscience Locomotion 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Acs Chemical Neuroscience, 7, 964-971 ACS Chemical Neuroscience ACS Chemical Neuroscience, American Chemical Society (ACS), 2016, 7 (7), pp.964-971. ⟨10.1021/acschemneuro.6b00087⟩ Acs Chemical Neuroscience, 7, 7, pp. 964-971 Europe PubMed Central |
| ISSN: | 1948-7193 |
| DOI: | 10.1021/acschemneuro.6b00087⟩ |
| Popis: | Striatal dopaminergic dysregulation in schizophrenia could result from a prefronto-striatal dysconnectivity, of neurodevelopmental origin, involving N-methyl-d-aspartate (NMDA) receptors. The dorsomedian shell part of the nucleus accumbens is a striatal subregion of particular interest inasmuch as it has been described as the common target region for antipsychotics. Moreover, NMDA receptors located on the dopaminergic endings have been reported in the shell. The present study examines in adult rats the effects of early functional inactivation of the left prefrontal cortex on behavioral and dopaminergic responses in the dorsomedian shell part of the nucleus accumbens following administration of two noncompetitive NMDA receptor antagonists, ketamine, and dizocilpine (MK-801). The results showed that postnatal blockade of the prefrontal cortex led to increased locomotor activity as well as increased extracellular dopamine levels in the dorsomedian shell following administration of both noncompetitive NMDA receptor antagonists, and, more markedly, after treatment with the more specific one, MK-801, whereas decreased dopaminergic levels were observed in respective controls. These data suggest a link between NMDA receptor dysfunctioning and dopamine dysregulation at the level of the dorsomedian shell part of the nucleus accumbens. They may help to understand the pathophysiology of schizophrenia in a neurodevelopmental perspective. |
| Databáze: | OpenAIRE |
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