No association between the SOCS-1 −1478CA/del polymorphism and ulcerative colitis in Turkish subjects
| Autor: | Adem Deligonul, Mustafa Hartavi, Selim Giray Nak, Barbaros Oral |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Turkey medicine.medical_treatment Suppressor of Cytokine Signaling Proteins Disease Age and sex Gastroenterology Young Adult Suppressor of Cytokine Signaling 1 Protein Internal medicine Odds Ratio Genetics medicine Humans Allele Molecular Biology Alleles Genetic Association Studies Colectomy Polymorphism Genetic business.industry General Medicine Odds ratio Middle Aged medicine.disease Ulcerative colitis Colonic mucosa Cytokine Case-Control Studies Immunology Colitis Ulcerative Female business |
| Zdroj: | Molecular Biology Reports. 41:6505-6508 |
| ISSN: | 1573-4978 0301-4851 |
| Popis: | Suppressor of cytokine signaling (SOCS)-1 is an essential regulator of many cytokine signaling pathways, including those upregulated in the inflamed colonic mucosa of patients with ulcerative colitis. We sought to investigate whether the functional SOCS-1 −1478CA>del polymorphism is associated with UC susceptibility and its disease phenotype in a Turkish clinical sample. A total of 104 subjects were enrolled in a case–control study (52 UC cases and 52 controls). The SOCS-1 −1478CA>del polymorphism was genotyped using a polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) method. The odds ratio of the del allele for UC relative to the CA allele was not significant (OR = 1.04, 95 % CI 0.59–1.82, P = 0.88). These results did not change after adjustment for age and sex in multivariable regression analysis (OR = 1.07, 95 % CI 0.42–1.69, P = 0.73). When the SOCS-1 −1478CA>del polymorphism was analyzed among UC patients according to continuous disease and non-continuous disease, the del allele was not associated with disease recurrence (OR = 1.56, 95 % CI 0.78–4.56, P = 0.83). Furthermore, when we divided UC patients into two groups according to a previous history of colectomy, we found no significant effect of the del allele (OR = 1.94, 95 % CI 0.55–5.61, P = 0.91). Taken together, these findings suggest that SOCS-1 −1478CA>del polymorphism does not contribute to UC susceptibility and its disease phenotype in Turkish subjects. |
| Databáze: | OpenAIRE |
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