How to erase memory traces of pain and fear
| Autor: | Jürgen Sandkühler, Jonathan L.C. Lee |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Nociception
Memory Long-Term Neuroscience(all) Conditioning Classical Long-Term Potentiation Models Neurological Pain Nerve Tissue Proteins Review Anxiety Models Psychological Receptors Ionotropic Glutamate Extinction Psychological medicine Memory formation Animals Humans Pain Management Protein Kinase Inhibitors Protein Kinase C General Neuroscience Fear Extinction (psychology) Pain management Rats Analgesics Opioid Isoenzymes Cycloserine Hyperalgesia Adaptive behaviour Mental Recall Well-being Pain psychology medicine.symptom Psychology Neuroglia Protein Kinases Neuroscience Cognitive psychology |
| Zdroj: | Trends in Neurosciences |
| ISSN: | 0166-2236 |
| Popis: | Highlights • Currently emerging concepts of maladaptive pain and fear suggest that they share basic neuronal circuits and cellular mechanisms of memory formation. • Recent studies have revealed processes of erasing memory traces of pain and fear that may be promising targets for future therapies. Pain and fear are both aversive experiences that strongly impact on behaviour and well being. They are considered protective when they lead to meaningful, adaptive behaviour such as the avoidance of situations that are potentially dangerous to the integrity of tissue (pain) or the individual (fear). Pain and fear may, however, become maladaptive if expressed under inappropriate conditions or at excessive intensities for extended durations. Currently emerging concepts of maladaptive pain and fear suggest that basic neuronal mechanisms of memory formation are relevant for the development of pathological forms of pain and fear. Thus, the processes of erasing memory traces of pain and fear may constitute promising targets for future therapies. |
| Databáze: | OpenAIRE |
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