Retinoids inhibit prolactin-induced development of the mammary gland in vitro
| Autor: | Rajendra G. Mehta, Richard C. Moon, Wendy L. Cerny |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Cancer Research
medicine.medical_specialty medicine.medical_treatment Mammary gland Biology Retinyl acetate medicine.disease_cause Mice chemistry.chemical_compound Mammary Glands Animal Organ Culture Techniques Internal medicine medicine Animals Vitamin A Mice Inbred BALB C Insulin DNA General Medicine In vitro Prolactin medicine.anatomical_structure Endocrinology chemistry Female Thymidine Carcinogenesis |
| Zdroj: | Carcinogenesis. 4:23-26 |
| ISSN: | 1460-2180 0143-3334 |
| DOI: | 10.1093/carcin/4.1.23 |
| Popis: | Mouse mammary gland organ culture technique was utilized to determine the effects of retinoids on the prolactin-induced structural differentiation of the mammary gland. Thoracic glands from BALB/c mice pretreated with steroids differentiate in 6 days into alveolar structures in presence of insulin and prolactin. All-trans-retinoic acid and N-(-4-hydroxyphenyl)retinamide inhibit prolactin-induced structural changes in the glands. Retinyl acetate, which is effective against mammary carcinogenesis in the rat, but is ineffective against mouse mammary carcinogenesis, failed to inhibit such proliferation. These results were correlated with inhibition of [3H]thymidine incorporation into DNA in a dose related manner by retinoids effective in inhibiting mammary development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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