Detection of HHV-6 in over a thousand samples: new types of infection revealed by an analysis of positive results
| Autor: | David Veyer, Christian Michelet, Sophie Minjolle, Gisèle Lagathu, Matthieu Revest, Ronald Colimon |
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| Přispěvatelé: | Service des maladies infectieuses et réanimation médicale [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou, Laboratoire de Virologie [CHU Rennes], CHU Pontchaillou [Rennes], Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], Laboratoire de Virologie [Rennes] = Virology [Rennes], Brébion, Alice |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
Pathology medicine.medical_treatment Herpesvirus 6 Human Neurological disorder Liver transplantation Polymerase Chain Reaction Infant Newborn Diseases 0302 clinical medicine MESH: Pregnancy MESH: Aged 80 and over Pregnancy MESH: Immunocompromised Host Encephalitis Viral Pregnancy Complications Infectious Aged 80 and over MESH: Aged 0303 health sciences MESH: Middle Aged biology MESH: Infant Newborn virus diseases Middle Aged MESH: Digestive System Diseases MESH: Infant 3. Good health MESH: Encephalitis Viral MESH: Infectious Disease Transmission Vertical Fetal Diseases Infectious Diseases MESH: Fetal Diseases [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology Child Preschool Encephalitis 030211 gastroenterology & hepatology Human herpesvirus 6 Female Immunocompetence Adult medicine.medical_specialty Adolescent Digestive System Diseases Roseolovirus Infections MESH: Infant Newborn Diseases HHV-6 03 medical and health sciences Immunocompromised Host Maternal-fetal infection MESH: Roseolovirus Infections Virology Internal medicine Febrile seizure medicine Humans Digestive ulcerations MESH: Pregnancy Complications Infectious Seroconversion [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology 030304 developmental biology Aged Retrospective Studies MESH: Adolescent MESH: Humans business.industry MESH: Child Preschool Infant Newborn Abortion Infant Retrospective cohort study MESH: Adult MESH: Polymerase Chain Reaction MESH: Retrospective Studies medicine.disease biology.organism_classification MESH: Herpesvirus 6 Human Infectious Disease Transmission Vertical MESH: Male MESH: DNA Viral MESH: Immunocompetence DNA Viral business MESH: Female |
| Zdroj: | Journal of Clinical Virology Journal of Clinical Virology, Elsevier, 2011, 51 (1), pp.20-4. ⟨10.1016/j.jcv.2011.02.001⟩ |
| ISSN: | 1386-6532 1873-5967 |
| DOI: | 10.1016/j.jcv.2011.02.001⟩ |
| Popis: | International audience; BACKGROUND: Clinical manifestations of human herpesvirus-6 (HHV-6) have not been clearly defined, and the role of HHV-6 in human disease remains to be fully elucidated. OBJECTIVE: To determine the frequency of HHV-6 infections at Rennes Teaching Hospital and to describe all possible symptoms of such infections. STUDY DESIGN: We systematically analyzed in a retrospective study all the samples between May 2003 and December 2004 from patients with HHV-6 by polymerase chain reaction (PCR). Clinical records of patients with positive HHV-6 PCR were recorded. Diagnosis of HHV-6 infection was accepted if all other possible diagnoses had been eliminated. RESULTS: Over the study period, 1591 PCRs were performed from various tissues, including blood, cerebrospinal fluid, ascitis and tissue biopsies. Forty-three samples from 25 patients tested positive (3%). We describe three groups of clinical manifestations of HHV-6 infection. The first group consisted of neurological complications (32% of patients), including convulsions, encephalitis and chronic psychiatric disorders in immunocompetent patients. The second group consisted of clinical problems relating to gastrointestinal tract, which was found in 9 of our patients (36%). All of these patients were immunocompromised. Four of them presented colitis, and one of them died one month after liver transplantation because of this colitis. The last group of clinical symptoms was associated with maternal-fetal infection leading to abortion following HHV-6 seroconversion during pregnancy. CONCLUSION: Three clinical types of HHV-6 infections are described: neurological manifestations including encephalitis in non-immunocompromised patients, digestive problems in immunosuppressed patients and severe maternal-fetal infection. |
| Databáze: | OpenAIRE |
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