Vascular endothelial growth factor and hypoxia-inducible factor-1α gene polymorphisms and coronary collateral formation in patients with coronary chronic total occlusions
| Autor: | Benjamin Wrigley, James Cotton, Eric W Holroyd, V Amoah, Angel L. Armesilla, Alan M. Nevill, Andrew Smallwood |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Rentrop grade gene polymorphism polymerase chain reaction Single-nucleotide polymorphism 030204 cardiovascular system & hematology Cardiovascular 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine In patient Gene chronic total occlusion lcsh:R5-920 vascular endothelial growth factor hypoxia-inducible factor-1α business.industry General Medicine Vascular endothelial growth factor Hypoxia-inducible factors chemistry 030220 oncology & carcinogenesis Cardiology Cancer research Original Article Gene polymorphism business lcsh:Medicine (General) |
| Zdroj: | SAGE Open Medicine, Vol 4 (2016) SAGE Open Medicine |
| ISSN: | 2050-3121 |
| Popis: | Introduction:We evaluated the association between two single nucleotide polymorphisms of the vascular endothelial growth factor gene and one of the hypoxia-inducible factor-1α gene and the degree of coronary collateral formation in patients with a coronary chronic total occlusion.Methods:Totally, 98 patients with symptomatic coronary artery disease and a chronic total occlusion observed during coronary angiography were recruited. Genotyping of two vascular endothelial growth factor promoter single nucleotide polymorphisms (−152G>A and −165C>T) and the C1772T single nucleotide polymorphism of hypoxia-inducible factor-1α were performed using polymerase chain reaction and restriction fragment length polymorphism analysis. The presence and extent of collateral vessel filling was scored by blinded observers using the Rentrop grade.Results:We found no association between the vascular endothelial growth factor −152G>A, −165C>T and hypoxia-inducible factor-1α −1772C>T with the presence and filling of coronary collateral vessels. A history of percutaneous coronary intervention and transient ischaemic attack/cerebrovascular accident were associated with the presence of enhanced collateral vessel formation following binary logistic regression analysis.Conclusion:The study findings suggest that coronary collateral formation is not associated with the tested polymorphic variants of vascular endothelial growth factor and hypoxia-inducible factor-1α in patients with symptomatic coronary artery disease and the presence of a chronic total occlusion. |
| Databáze: | OpenAIRE |
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