Antibodies to tissue-type plasminogen activator (t-PA) in patients with inflammatory bowel disease: high prevalence, interactions with functional domains of t-PA and possible implications in thrombosis
| Autor: | M. Boscolo Anzoletti, Simone Saibeni, Massimo Cugno, Maurizio Vecchi, C. Ciscato, R. De Franchis, Ewa Kaczmarek, Sonia Caccia |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_treatment Inflammatory bowel disease Epitope Immunoglobulin G Epitopes Kringles Catalytic Domain Fibrinolysis medicine Prevalence Humans Autoantibodies Crohn's disease biology business.industry Case-control study Thrombosis Hematology Middle Aged medicine.disease Inflammatory Bowel Diseases Protein Structure Tertiary Case-Control Studies Tissue Plasminogen Activator Immunology biology.protein Female Antibody business Plasminogen activator |
| Zdroj: | Journal of thrombosis and haemostasis : JTH. 4(7) |
| ISSN: | 1538-7933 |
| Popis: | Summary. Background: Patients with inflammatory bowel disease (IBD) have an increased prevalence of thromboembolic events. The pathogenetic mechanisms of these events include reduced fibrinolysis, which may be caused by antibodies to tissue-type plasminogen activator (t-PA). Objectives: To evaluate anti-t-PA antibodies in patients with IBD, considering clinical, biochemical and functional characteristics. Patients and methods: We immunoenzymatically measured anti-t-PA antibodies in plasma from 97 consecutive IBD patients and 97 age- and sex-matched healthy controls. We also assessed the antibody interactions with different epitopes of t-PA, the antibody inhibition on t-PA activity and the correlations with clinical features and other serum antibodies. Results: IBD patients had higher median anti-t-PA antibody levels (5.4 U mL−1 vs. 4.0 U mL−1; P |
| Databáze: | OpenAIRE |
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