Expression of tripartite motif-containing 44 and its prognostic and clinicopathological value in human malignancies:a meta-analysis

Autor: Ziwei Bao, Guo-Liang Xiao, Haixia Mao, Shibu Lin, Qiu-Xi Yang, Yi Zhang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Antineoplastic Agents
lcsh:RC254-282
Disease-Free Survival
Tripartite Motif Proteins
03 medical and health sciences
0302 clinical medicine
Tripartite Motif
Surgical oncology
Predictive Value of Tests
Internal medicine
Neoplasms
Genetics
medicine
Biomarkers
Tumor
Humans
Neoplasm Invasiveness
Stage (cooking)
Neoplasm Staging
business.industry
Hazard ratio
Intracellular Signaling Peptides and Proteins
Cancer
Cell Differentiation
Odds ratio
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
Gene expression profiling
Meta-analysis
030104 developmental biology
030220 oncology & carcinogenesis
Feasibility Studies
Neoplasm Recurrence
Local
business
Clinicopathological features
Research Article
TRIM44
Zdroj: BMC Cancer
BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
ISSN: 1471-2407
Popis: Background Previous researches have reported that tripartite motif-containing 44 (TRIM44) is related to the prognosis of multiple human tumors. This study was designed to systematically assess the prognostic value of TRIM44 in human malignancies and summarize its possible tumor-related mechanisms. Methods The available databases were searched for eligible studies that evaluated the clinicopathological and prognostic roles of TRIM44 in patients with malignancies. The hazard ratios (HR) and odds ratios (OR) were combined to assess the predictive role of TRIM44 using Stata/SE 14.1 software. Results A total of 1740 patients from thirteen original studies were finally included in this study. The results of the combined analysis showed that over-expression of TRIM44 protein was significantly correlated with shorter overall survival (OS) (HR = 1.94, 95% CI: 1.60–2.35) and worse disease-free survival (DFS) (HR = 2.13, 95% CI: 1.24–3.65) in cancer patients. Additionally, the combined ORs indicated that elevated expression level of TRIM44 protein was significantly associated with lymph node metastasis (OR = 2.69, 95% CI: 1.71–4.24), distant metastasis (OR = 10.35, 95% CI: 1.01–106.24), poor tumor differentiation (OR = 1.78, 95% CI: 1.03–3.09), increased depth of tumor invasion (OR = 2.72, 95% CI: 1.73–4.30), advanced clinical stage (OR = 2.75, 95% CI: 2.04–3.71), and recurrence (OR = 2.30, 95% CI: 1.34–3.95). Furthermore, analysis results using Gene Expression Profiling Interactive Analysis (GEPIA) showed that the expression level of TRIM44 mRNA was higher in most tumor tissues than in the corresponding normal tissues, and the relationship between TRIM44 mRNA level and prognosis in various malignant tumors also explored in GEPIA and OS analysis webservers. Conclusions TRIM44 may serve as a valuable prognostic biomarker and a potential therapeutic target for patients with malignancies.
Databáze: OpenAIRE
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