Impact of Iodinated Contrast on Renal Function and Hemodynamics in Rats with Chronic Hyperglycemia and Chronic Kidney Disease
| Autor: | Sheila Marques Fernandes, Cassiane Dezoti da Fonseca, Mirian Watanabe, Daniel Malisani Martins, Maria de Fátima Fernandes Vattimo |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Article Subject medicine.medical_treatment 030232 urology & nephrology Urology Hemodynamics Renal function Contrast Media lcsh:Medicine 030204 cardiovascular system & hematology Kidney urologic and male genital diseases Nephrectomy General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Iodinated contrast Internal medicine Medicine Animals Humans Renal Insufficiency Chronic General Immunology and Microbiology business.industry lcsh:R Acute kidney injury Inulin General Medicine medicine.disease Rats Endocrinology medicine.anatomical_structure Renal blood flow Hyperglycemia Vascular Resistance business Kidney disease Iodine Research Article |
| Zdroj: | BioMed Research International, Vol 2016 (2016) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Iodinated contrast (IC) is clinically used in diagnostic and interventional procedures, but its use can result in contrast-induced acute kidney injury (CI-AKI). Chronic kidney disease (CKD) and chronic hyperglycemia (CH) are important predisposing factors to CI-AKI. The aim of this study was to investigate the impact of iodinated contrast on the renal function and hemodynamics in rats with chronic hyperglycemia and chronic kidney disease. A total of 30 rats were divided into six groups; Sham: control of chronic renal disease; Citrate: control of chronic hyperglycemia (CH); Nx5/6: rats with 5/6 nephrectomy; Chronic Hyperglycemia: rats receiving Streptozotocin 65 mg/kg; Nx5/6 + IC: rats Nx5/6 received 6 mL/kg of IC; CH + IC: Chronic hyperglycemia rats receiving 6 mL/kg of IC. Renal function (inulinclearance; urinary neutrophil gelatinase-associated lipocalin, NGAL) and hemodynamics (arterial blood pressure; renal blood flow; renal vascular resistance) were evaluated. Iodinated contrast significantly increased urinary NGAL and reduced inulinclearance, while the hemodynamics parameters showed changes in arterial blood pressure, renal blood flow, and renal vascular resistance in both CKD and CH groups. The results suggest that the iodinated contrast in risk factors models has important impact on renal function and hemodynamics. NGAL was confirmed to play a role of highlight in diagnosis of CI-AKI. |
| Databáze: | OpenAIRE |
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