Possible Therapeutic Applications of Targeting STAP Proteins in Cancer

Autor: Tadashi Matsuda, Kenji Oritani
Jazyk: angličtina
Rok vydání: 2021
Předmět:
STAT3 Transcription Factor
STAT3 Transcription Factor/metabolism
Signal Transduction
signal-transducing adaptor protein (STAP)
Carcinogenesis
Neoplasm Proteins/metabolism
Humans
Pharmaceutical Science
Tumor Suppressor Proteins/metabolism
cancer cell growth
Adaptor Proteins
Signal Transducing/metabolism
Neoplasms
STAT5 Transcription Factor
Animals
STAT3
STAT5
Adaptor Proteins
Signal Transducing
Pharmacology
biology
Kinase
Tumor Suppressor Proteins
Protein-Tyrosine Kinases/metabolism
Signal transducing adaptor protein
Blood Proteins
General Medicine
Protein-Tyrosine Kinases
Phosphoproteins
Carcinogenesis/metabolism
Tyrosine/metabolism
Neoplasm Proteins
Cell biology
Pleckstrin homology domain
tumorigenesis
STAT5 Transcription Factor/metabolism
STAT protein
biology.protein
Tyrosine
Neoplasms/metabolism
Blood Proteins/metabolism
Phosphoproteins/metabolism
Signal transduction
signal transduction
Proto-oncogene tyrosine-protein kinase Src
adaptor protein
Zdroj: Biological & pharmaceutical bulletin. 44(12):1810-1818
ISSN: 0918-6158
Popis: The signal-transducing adaptor protein (STAP) family, including STAP-1 and STAP-2, contributes to a variety of intracellular signaling pathways. The proteins in this family contain typical structures for adaptor proteins, such as Pleckstrin homology in the N-terminal regions and SRC homology 2 domains in the central regions. STAP proteins bind to inhibitor of kappaB kinase complex, breast tumor kinase, signal transducer and activator of transcription 3 (STAT3), and STAT5, during tumorigenesis and inflammatory/immune responses. STAP proteins positively or negatively regulate critical steps in intracellular signaling pathways through individually unique mechanisms. This article reviews the roles of the novel STAP family and the possible therapeutic applications of targeting STAP proteins in cancer.
Databáze: OpenAIRE
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