Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis
| Autor: | Manish J. Butte, Ya-Yuan Fu, Monalee Saha, Pankaj J. Pasricha, Michael G. Anderson, Raj P. Kapur, Xiling Shen, Maria-Adelaide Micci, Qian Li, E. Michelle Southard-Smith, Laren Becker, Shiue-Cheng Tang, Jenna Leser, Milena Bogunovic, Hongjun Song, Xinzhong Dong, Liansheng Liu, Grigori Enikolopov, Subhash Kulkarni, Nikolai Rakhilin, Cuiping Li, Changsik Shin |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
neuronal apoptosis enteric neural precursor cells Neurogenesis 1.1 Normal biological development and functioning SOX10 Mice Transgenic Apoptosis Receptors Nerve Growth Factor enteric neurons Biology Enteric Nervous System Transgenic Nestin 03 medical and health sciences Mice Underpinning research Precursor cell Receptors Nerve Growth Factor Tensin Animals Humans Multidisciplinary SOXE Transcription Factors Neurosciences Stem Cell Research adult neurogenesis 030104 developmental biology PNAS Plus nervous system Neurological Enteric nervous system Stem Cell Research - Nonembryonic - Non-Human Digestive Diseases Neuroscience Ganglioneuromatosis |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 18 |
| Popis: | According to current dogma, there is little or no ongoing neurogenesis in the fully developed adult enteric nervous system. This lack of neurogenesis leaves unanswered the question of how enteric neuronal populations are maintained in adult guts, given previous reports of ongoing neuronal death. Here, we confirm that despite ongoing neuronal cell loss because of apoptosis in the myenteric ganglia of the adult small intestine, total myenteric neuronal numbers remain constant. This observed neuronal homeostasis is maintained by new neurons formed in vivo from dividing precursor cells that are located within myenteric ganglia and express both Nestin and p75NTR, but not the pan-glial marker Sox10. Mutation of the phosphatase and tensin homolog gene in this pool of adult precursors leads to an increase in enteric neuronal number, resulting in ganglioneuromatosis, modeling the corresponding disorder in humans. Taken together, our results show significant turnover and neurogenesis of adult enteric neurons and provide a paradigm for understanding the enteric nervous system in health and disease. |
| Databáze: | OpenAIRE |
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