Immunological monitoring in patients with end-stage renal disease
| Autor: | Liling Shen, Radoslav J. Bachvaroff, A.P. Raisbeck, Bjorg Egelandsdal, Wayne C. Waltzer, Pullis Ck, Felix T. Rapaport |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
Male medicine.medical_specialty Immunology chemical and pharmacologic phenomena Disease T-Lymphocytes Regulatory End stage renal disease Immune system Medical microbiology Antigen Dinitrochlorobenzene Immunology and Allergy Medicine Humans In patient Hypersensitivity Delayed Skin Tests Diminution Immunity Cellular business.industry T-Lymphocytes Helper-Inducer Killer Cells Natural Kidney Failure Chronic Female business K562 cells |
| Zdroj: | Journal of clinical immunology. 4(5) |
| ISSN: | 0271-9142 |
| Popis: | Parameters of cell-mediated immune function were determined in 76 patients with end-stage renal disease. Lymphocyte subpopulations (OKT3, OKT4, OKT8, OKIa1, OKM1, OKT9, OKT10), natural killer (NK)-cell activity (percentage 51Cr release from K562 targets), and delayed cutaneous hypersensitivity were measured and correlated with other variables. The results indicate that (1) uremic patients have a significant diminution in the OKT4-lymphocyte subpopulation and OKT4/OKT8 (helper/suppressor) ratio compared to normal controls; (2 blood transfusions do not induce significant alterations in the helper/suppressor-cell ratio; (3) uremic patients have a significant increase in OKM1 cells compared to normal controls; (4) the majority of uremic patients in this series developed delayed cutaneous hypersensitivity responses to recall antigens and could be de novo sensitized to 2,4-dinitrochlorobenzene (DNCB); (5) skin-test reactivity could not be correlated with total circulating T cells or levels of any lymphocyte subpopulations; and (6) NK-cell activity in uremic patients is not significantly different from that in normal controls. These results highlight the varying levels and function of different lymphocyte subsets in patients with end-stage renal disease when they are treated with chronic maintenance hemodialysis. |
| Databáze: | OpenAIRE |
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