The potential value of serum pepsinogen for the diagnosis of atrophic gastritis among the health check-up populations in China: a diagnostic clinical research
| Autor: | Xinyan Yu, Yingying Yu, Yuling Tong, Zhenya Song, Yulian Wu |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Gastritis Atrophic Male medicine.medical_specialty China Pepsinogen A Atrophic gastritis Gastroenterology Helicobacter pylori infection Helicobacter Infections 03 medical and health sciences 0302 clinical medicine Atrophy Reference Values Internal medicine medicine Humans Mass Screening lcsh:RC799-869 Mass screening biology Helicobacter pylori business.industry Health check-up General Medicine Hepatology Middle Aged biology.organism_classification medicine.disease 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Histopathology lcsh:Diseases of the digestive system. Gastroenterology Female Gastritis medicine.symptom business Serum pepsinogen Research Article |
| Zdroj: | BMC Gastroenterology BMC Gastroenterology, Vol 17, Iss 1, Pp 1-7 (2017) |
| ISSN: | 1471-230X |
| Popis: | Background The aim of this study is to assess the validity of the measurement of pepsinogen as a screening test for chronic atrophic gastritis (AG) in health check-up populations in China. Methods Patients from consecutive regular health check-up were enrolled from January 2014 to June 2015. Endoscopy, combined with monitoring the Helicobacter pylori (Hp) infections, and measuring the serum pepsinogen (PG) were used to determine the diagnostic accuracy of PG for the screening of atrophic gastritis. Histopathology was assessed by the Operative Link on Gastritis Assessment (OLGA) system. Statistical analysis was performed using SPSS statistical software. Results The total Hp infection rate was 40%. Based on pathology, the 996 participants were divided into three groups: non-atrophic (NAG), mild-moderate atrophic (MAG): stage I and II of the OLGA classification, and severe atrophic (SAG): stage III and IV of the OLGA classification. Compared with NAG and MAG groups, PGR decreased significantly in SAG group (p |
| Databáze: | OpenAIRE |
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