Investigation of metastasis-associated in colon cancer-1 genetic variants in the development and clinicopathologcial characteristics of uterine cervical cancer in Taiwanese women
| Autor: | Huang-Pin Shen, Yi-Hung Sun, Chu-Chyn Ou, Chun-Fang Hsu, Soo-Cheen Ng, Shun-Fa Yang, Yueh-Chun Lee, Ying-Hsiang Chou, Po-Hui Wang |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Genotype Colorectal cancer Taiwan Uterine Cervical Neoplasms Cervical intraepithelial neoplasia Polymerase Chain Reaction Polymorphism Single Nucleotide Metastasis single nucleotide polymorphisms 03 medical and health sciences 0302 clinical medicine Asian People Internal medicine medicine Humans Genetic Predisposition to Disease Lymph node Survival rate metastasis-associated in colon cancer-1 Aged Retrospective Studies Cervical cancer business.industry vaginal invasion Positive Pelvic Lymph Node General Medicine Middle Aged medicine.disease Survival Rate medicine.anatomical_structure Trans-Activators Female 030211 gastroenterology & hepatology 5 years survival rate business uterine cervical cancer Research Paper |
| Zdroj: | International Journal of Medical Sciences |
| ISSN: | 1449-1907 |
| DOI: | 10.7150/ijms.40204 |
| Popis: | The objectives of this study were to define the associations among single nucleotide polymorphisms (SNPs) of metastasis-associated in colon cancer-1 (MACC1) gene, development and clinicopathological characteristics of uterine cervical cancer, and patient survival in Taiwan. Genotypic frequencies of 5 MACC1 SNPs rs975263, rs3095007, rs4721888, rs3735615 and rs1990172 were identified for 132 patients with invasive cancer, 99 with high-grade cervical intraepithelial neoplasia and 338 normal controls using real-time polymerase chain reaction. It revealed that there were no associations of these MACC1 SNPs with cervical carcinogenesis. In the meantime, cervical cancer patients with genotype GG in MACC1 SNP rs975263 tended to display more risk to have vaginal invasion than those with AA/AG (p=0.042, OR: 8.70, 95% CI: 0.81-433.22). In multivariate analysis, positive pelvic lymph node metastasis could significantly predict worse 5 years survival rate (p=0.001; HR=9.98, 95% CI=2.64-37.77) for cervical cancer patients. In conclusion, pelvic lymph node status rather than MACC1 SNPs was the only independent parameter that could significantly predict 5 years survival rate in Taiwanese women with cervical cancer. |
| Databáze: | OpenAIRE |
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