Self-reported childhood trauma correlates with schizotypal measures in schizophrenia but not bipolar pedigrees
| Autor: | Helen L. Fisher, Marion Leboyer, Caroline Soussy, Audrey Laguerre, Franck Schürhoff, Andrei Szöke, Bruno Etain, Alexandre Méary |
|---|---|
| Přispěvatelé: | Institut Mondor de recherche biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service de psychiatrie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Hôpital Albert Chenevier, Department of Psychological Medicine, Institute of psychiatry, This work was supported by grants from the Agence Nationale de la Recherche (Manage-BP), the Fondation pour la Recherche sur le Cerveau, The RTRS (Réseau Thématique Translationel de Recherche et de Soins) and the Institut de la Santé et de la Recherche Médicale (INSERM), Guellaen, Georges |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Child abuse Psychosis medicine.medical_specialty Bipolar Disorder Schizotypy Poison control Comorbidity Article Schizotypal Personality Disorder 03 medical and health sciences 0302 clinical medicine Surveys and Questionnaires medicine [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology Humans Family Genetic Predisposition to Disease [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Child Abuse Bipolar disorder Child Psychiatry Applied Psychology medicine.disease Schizotypal personality disorder Pedigree 030227 psychiatry Psychiatry and Mental health Schizophrenia Female France Psychology 030217 neurology & neurosurgery |
| Zdroj: | Psychological Medicine Psychological Medicine, Cambridge University Press (CUP), 2009, 39 (3), pp.365-70. ⟨10.1017/S0033291708003905⟩ |
| ISSN: | 0033-2917 1469-8978 |
| Popis: | BackgroundStrong evidence supports the association between childhood trauma and psychotic disorders. In two different high-risk populations, we looked for a correlation between the magnitude of schizotypal dimensions and the importance of self-reported childhood trauma.MethodA sample of 138 unaffected first-degree relatives was recruited (67 relatives of schizophrenic probands and 71 relatives of bipolar probands). The relationship between schizotypal dimensions and childhood trauma scores was analyzed by partial correlations.ResultsA positive correlation was found between childhood trauma scores and total schizotypal scores in first-degree relatives of schizophrenic subjects but not in first-degree relatives of bipolar probands. This correlation was primarily due to a strong association with the positive dimension of schizotypy.ConclusionsThe significant correlation between childhood trauma and schizotypal dimensions in subjects at high genetic risk for schizophrenia suggests that susceptibility genes for schizophrenia may interact with childhood trauma to induce the emergence of schizotypal dimensions, mainly positive psychotic features. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|