Bamboo shavings derived O-acetylated xylan alleviates loperamide-induced constipation in mice
| Autor: | Hang Xiao, Yi Zheng, Qi Wang, Ying Zhang, Zhenglu Xie, Juqing Huang, Bin Lin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Loperamide Constipation Polymers and Plastics Colon Inflammation Gut flora Pharmacology medicine.disease_cause Feces Mice Lactobacillus Materials Chemistry medicine Animals Gastrointestinal Transit Mice Inbred BALB C biology Bacteria Chemistry Organic Chemistry Pathogenic bacteria biology.organism_classification Fatty Acids Volatile Gastrointestinal Microbiome Defecation Xylans medicine.symptom Roseburia Gastrointestinal Motility Sasa Transcriptome medicine.drug |
| Zdroj: | Carbohydrate polymers. 276 |
| ISSN: | 1879-1344 |
| Popis: | BSH-1 is an O-acetylated xylan obtained from bamboo shavings. This study determined the protective effects of BSH-1 against loperamide (Lop)-induced constipation in mice. Mice received BSH-1 by gavage daily for 14 days. In constipated mice, BSH-1 significantly shortened the defecation time and raised the gastrointestinal (GI) transit rate, stool production, and cecal concentration of short-chain fatty acids (SCFAs). BSH-1 regulated the serum levels of gut hormones and neurotransmitters. BSH-1 also significantly altered the cecal microbiota of the constipated mice by increasing the abundance of potentially beneficial bacteria (e.g., Lactobacillus, Roseburia, and Bacteroidales_S24–7) and decreasing potentially pathogenic bacteria (e.g., Alloprevotella and Staphylococcus). Furthermore, colonic transcriptome analysis revealed that BSH-1 significantly reversed the expression changes of genes related to intestinal motility, water and ion transport, inflammation and cancer in constipated mice. Our findings indicated that BSH-1 effectively relieved Lop-induced constipation in mice and could be potentially used for constipation treatment. |
| Databáze: | OpenAIRE |
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