Potentials evoked in the intermediolateral column by hypothalamic stimulation - suppression by Δ9-tetrahydrocannabinol
| Autor: | Michael J. Hosko, William T. Schmeling, Harold F. Hardman |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
Bradycardia medicine.medical_specialty Hypothalamus Blood Pressure Stimulation General Biochemistry Genetics and Molecular Biology Membrane Potentials chemistry.chemical_compound Heart Rate Internal medicine mental disorders medicine Animals Dronabinol General Pharmacology Toxicology and Pharmaceutics Tetrahydrocannabinol CATS Chemistry Chloralose organic chemicals General Medicine Electric Stimulation Kinetics Endocrinology Spinal Cord Cats Female Hypothalamic stimulation Δ9-tetrahydrocannabinol medicine.symptom Histamine medicine.drug |
| Zdroj: | Life Sciences. 29:673-680 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(81)90019-9 |
| Popis: | Δ 9 -Tetrahydrocannabinol (THC), the primary psychoactive component of marihuana produces pronounced effects on the cardiovascular system including bradycardia and hypotension. A decrease in sympathetic activity may contribute to these actions. In chloralose urethane anesthetized cats, THC (2 mg/kg, i.v.) produced significant bradycardia, hypotension and attenuation of threshold pressor responses induced by hypothalamic stimulation. Evoked potentials recorded in the intermediolateral cell column (ILC) by stimulation of these hypothalamic pressor sites were significantly altered after THC. Hypotension induced by histamine administration (5 μg/kg, i.v.) altered ILC potentials before and after THC. These results support the hypothesis that THC reduces sympathetic outflow and reversibly resets the level of central cardiovascular homeostasis. |
| Databáze: | OpenAIRE |
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