Urinary excretion of argininosuccinic acid
| Autor: | E.Ann Burgess, T. Palmer, V. G. Oberholzer, B. Levin |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Adult
Male medicine.medical_specialty Heterozygote Chromatography Paper Urinary system Clinical Biochemistry Normal urine Biology Arginine Biochemistry Argininosuccinate lyase activity Excretion chemistry.chemical_compound Urinary excretion Internal medicine medicine Humans Electrophoresis Paper Amino Acid Metabolism Inborn Errors Argininosuccinic acid Autoanalysis Biochemistry (medical) Homozygote Infant Newborn Heterozygote advantage Succinates General Medicine Middle Aged Chromatography Ion Exchange Red blood cell Endocrinology medicine.anatomical_structure chemistry Barium Female |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 47(3) |
| ISSN: | 0009-8981 |
| Popis: | The urinary excretion of argininosuccinic acid in normal individuals and in heterozygotes for argininosuccinic-aciduria has been investigated. It was found that, contrary to what has been supposed, normal urine contains small but measurable quantities of argininosuccinic acid, up to 1.9 mg/day. The urinary excretion of the parents in two families with affected children, and therefore presumed heterozygotes, was 2.5–15.2 mg/day. Thus a distinction was made between normals and heterozygotes. However the difference was small and would not necessarily be clear cut if a larger number of normal people were examined. In one family, urinary argininosuccinic acid excretion gave a better indication of the heterozygote state than red blood cell argininosuccinate lyase activity. |
| Databáze: | OpenAIRE |
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