Positively Charged Nanostructured Lipid Carriers and Their Effect on the Dissolution of Poorly Soluble Drugs
| Autor: | Seokjin Suh, Sanghoon Ko, Kyeong-Ok Choi, Jaehyeog Choe |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Drug
Drug Liberation Chemistry Pharmaceutical media_common.quotation_subject in vitro release Biological Availability Pharmaceutical Science poorly water soluble drug indomethacin nanostructured lipid nanocarrier N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride 02 engineering and technology 030226 pharmacology & pharmacy Article Analytical Chemistry lcsh:QD241-441 Chitosan 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems 0302 clinical medicine lcsh:Organic chemistry Drug Discovery Humans Organic chemistry Physical and Theoretical Chemistry Solubility Dissolution media_common Drug Carriers Aqueous solution Organic Chemistry Water Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Lipids Bioavailability chemistry Chemical engineering Chemistry (miscellaneous) Nanoparticles Molecular Medicine 0210 nano-technology Drug carrier |
| Zdroj: | Molecules Molecules; Volume 21; Issue 5; Pages: 672 Molecules, Vol 21, Iss 5, p 672 (2016) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules21050672 |
| Popis: | The objective of this study is to develop suitable formulations to improve the dissolution rate of poorly water soluble drugs. We selected lipid-based formulation as a drug carrier and modified the surface using positively charged chitosan derivative (HTCC) to increase its water solubility and bioavailability. Chitosan and HTCC-coated lipid particles had higher zeta-potential values than uncoated one over the whole pH ranges and improved encapsulation efficiency. In vitro drug release showed that all NLC formulations showed higher in vitro release efficiency than drug particle at pH 7.4. Furthermore, NLC formulation prepared with chitosan or HTCC represented good sustained release property. The results indicate that chitosan and HTCC can be excellent formulating excipients of lipid-based delivery carrier for improving poorly water soluble drug delivery. |
| Databáze: | OpenAIRE |
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