ASSOCIATION OF DARK-ADAPTED VISUAL FUNCTION WITH RETINAL STRUCTURAL CHANGES IN PATIENTS WITH STARGARDT DISEASE
Autor: | Mohamed A. Genead, J. Jason McAnany, Gerald A. Fishman, Serena Salvatore |
---|---|
Rok vydání: | 2014 |
Předmět: |
Adult
Male medicine.medical_specialty genetic structures Visual Acuity Dark Adaptation Article Retina Ophthalmoscopy Macular Degeneration Young Adult chemistry.chemical_compound Optics Optical coherence tomography Ophthalmology medicine Humans Stargardt Disease External limiting membrane Retinal pigment epithelium medicine.diagnostic_test business.industry Retinal General Medicine Middle Aged medicine.disease Stargardt disease medicine.anatomical_structure chemistry Visual Field Tests Female sense organs Visual Fields business Tomography Optical Coherence Photoreceptor inner segment |
Zdroj: | Retina. 34:989-995 |
ISSN: | 0275-004X |
Popis: | PURPOSE To evaluate dark-adapted retinal sensitivity in patients with Stargardt disease (STGD1) using a modified MP-1 microperimeter and to compare the sensitivity loss with structural changes observed using spectral domain optical coherence tomography and confocal scanning laser ophthalmoscope infrared imaging. METHODS Twelve STGD1 patients and 10 normally sighted controls participated. Dark-adapted mean sensitivity (MS) was obtained using a MP-1 microperimeter. Additionally, MS percent difference between the patients and the controls was obtained. Sensitivity results were superimposed on confocal scanning laser ophthalmoscope infrared images and compared with corresponding spectral domain optical coherence tomography scans. RESULTS Dark-adapted MS ± standard deviation was 8.34 ± 1.54 dB for the controls and 3.68 ± 1.74 dB for STGD1 patients (P < 0.001). There was a significant reduction in MS of 24.0% in these patients. Sensitivity reductions were observed in areas that showed changes on confocal scanning laser ophthalmoscope infrared images and on spectral domain optical coherence tomography, including disorganizational loss of the retinal pigment epithelium, and abnormal photoreceptor inner segment ellipsoid and external limiting membrane reflectance bands. CONCLUSION With topographical accuracy, dark-adapted MS measurements can be made in STGD1 patients and controls using the MP-1 microperimeter. Sensitivity loss is associated with structural changes. This finding can be useful for the determination of optimal areas for potential improvement of retinal function in patients with Stargardt disease. |
Databáze: | OpenAIRE |
Externí odkaz: |