Process Design and Optimization in the Pharmaceutical Industry: A Suzuki-Miyaura Procedure for the Synthesis of Savolitinib
| Autor: | Gareth P. Howell, Michael John Pilling, Andrew Hornby Dobson, Lucie Miller-Potucka, Lauren R. Agnew, Robert J Cox, Brian A. Taylor, Adlington Neil Keith, Aled Williams, William Hicks, Gall Malcolm Allan Young, Andrew D. Campbell, Anna Jawor-Baczynska, Katy Shepherd, Cristina Fernandez Barrat, Ross Tassone |
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| Rok vydání: | 2018 |
| Předmět: |
Drug Industry
Molecular Structure 010405 organic chemistry Process (engineering) business.industry Chemistry Triazines Organic Chemistry Process design 010402 general chemistry 01 natural sciences Manufacturing engineering 0104 chemical sciences High-Throughput Screening Assays Drug Design Pyrazines business Drug industry Pharmaceutical industry |
| Zdroj: | The Journal of organic chemistry. 84(8) |
| ISSN: | 1520-6904 |
| Popis: | A multidisciplinary approach covering synthetic, physical, and analytical chemistry, high-throughput experimentation and experimental design, process engineering, and solid-state chemistry is used to develop a large-scale (kilomole) Suzuki–Miyaura process. Working against clear criteria and targets, a full process investigation and optimization package is described highlighting how and why key decisions are made in the development of large-scale pharmaceutical processes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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