C60 Fullerene as Promising Therapeutic Agent for the Prevention and Correction of Skeletal Muscle Functioning at Ischemic Injury
| Autor: | T Yu Matvienko, K. I. Bogutska, Dmytro M Nozdrenko, Peter Scharff, Yu. I. Prylutskyy, S Yu Zay, Danyloaniil A. Zavodovskyi, Uwe Ritter |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Materials science Skeletal muscle 02 engineering and technology Pharmacology 03 medical and health sciences chemistry.chemical_compound Materials Science(all) In vivo Ischemia Lactate dehydrogenase medicine General Materials Science Soleus muscle Muscle fatigue biology Nano Express C60 fullerene Therapeutic effect Muscular system 021001 nanoscience & nanotechnology Condensed Matter Physics Surgery 030104 developmental biology medicine.anatomical_structure chemistry Biochemical analysis biology.protein Muscle contraction dynamics Creatine kinase 0210 nano-technology |
| Zdroj: | Nanoscale Research Letters |
| ISSN: | 1556-276X 1931-7573 |
| Popis: | The therapeutic effect of pristine C60 fullerene aqueous colloid solution (C60FAS) on the functioning of the rat soleus muscle at ischemic injury depending on the time of the general pathogenesis of muscular system and method of administration C60FAS in vivo was investigated. It was found that intravenous administration of C60FAS is the optimal for correction of speed macroparameters of contraction for ischemic muscle damage. At the same time, intramuscular administration of C60FAS shows pronounced protective effect in movements associated with the generation of maximum force responses or prolonged contractions, which increase the muscle fatigue level. Analysis of content concentration of creatine phosphokinase and lactate dehydrogenase enzymes in the blood of experimental animals indicates directly that C60FAS may be a promising therapeutic agent for the prevention and correction of ischemic-damaged skeletal muscle function. |
| Databáze: | OpenAIRE |
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