Pharmacological evaluation of aqueous extract of Althaea officinalis flower grown in Lebanon
| Autor: | Mohamad Mroueh, Costantine F. Daher, Rouba Hage-Sleiman |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.drug_class Drug Evaluation Preclinical Pharmaceutical Science Context (language use) Flowers Anti-inflammatory Althaea Rats Sprague-Dawley Drug Discovery medicine Althaea officinalis Animals Edema Stomach Ulcer Lebanon Pharmacology Aqueous extract Folk medicine biology Traditional medicine business.industry Plant Extracts ALTHAEA OFFICINALIS FLOWER General Medicine biology.organism_classification Rats Liver metabolism Complementary and alternative medicine Liver Molecular Medicine business |
| Zdroj: | Pharmaceutical biology. 49(3) |
| ISSN: | 1744-5116 |
| Popis: | Althaea officinalis Linn. (Malvaideae) flower is commonly used in folk medicine in Lebanon and neighboring countries. Although most of the studies have been conducted on the mucilage-rich roots, little is known about the flower.This study investigates the potential role of aqueous extract of Althaea officinalis flower in lipemia, gastric ulcer, inflammation, and platelet aggregation using the rat model.Blood lipid profile and liver function were assessed after 1 month of extract intake via drinking water. Anti-inflammatory activity was tested against acute and chronic inflammation induced by carrageenan and formalin, respectively. Antiulcer activity was evaluated using ethanol-induced gastric ulcer. Antiplatelet activity was investigated in vitro using the adenosine 5'-diphosphate (ADP)-induced platelet aggregation bioassay.The 50 mg/kg body weight dose resulted in significant increase in serum HDL cholesterol level with no effects on stool cholesterol and triacylglycerol. Increasing the dose to 500 mg/kg body weight caused a significant decrease in stool water content. No adverse effect on liver enzymes was observed. Significant anti-inflammatory (acute and chronic inflammation) and antiulcerogenic activities were observed at all used doses (50, 100, and 250 mg/kg body). Time-dependent inhibition of platelet aggregation was demonstrated at 500 µg/ml concentration.The aqueous extract of Althaea officinalis flower demonstrated potential benefits in lipemia, inflammation, gastric ulcer, and platelet aggregation with no visible adverse effect. |
| Databáze: | OpenAIRE |
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